| pubmed-article:19068483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19068483 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:19068483 | lifeskim:mentions | umls-concept:C1157677 | lld:lifeskim |
| pubmed-article:19068483 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19068483 | lifeskim:mentions | umls-concept:C0450240 | lld:lifeskim |
| pubmed-article:19068483 | lifeskim:mentions | umls-concept:C1706210 | lld:lifeskim |
| pubmed-article:19068483 | lifeskim:mentions | umls-concept:C2347567 | lld:lifeskim |
| pubmed-article:19068483 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19068483 | pubmed:dateCreated | 2009-2-2 | lld:pubmed |
| pubmed-article:19068483 | pubmed:abstractText | The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is highly conserved throughout evolution and regulates cell size and survival and cell cycle progression. It regulates the latter by stimulating procession through G(1) and the G(1)/S phase transition. Entry into S phase requires an abundant supply of purine nucleotides, but the effect of the PI3K/Akt pathway on purine synthesis has not been studied. We now show that the PI3K/Akt cassette regulates both de novo and salvage purine nucleotide synthesis in insulin-responsive mouse mesenchymal cells. We found that serum and insulin stimulated de novo purine synthesis in serum-starved cells largely through PI3K/Akt signaling, and pharmacologic and genetic inhibition of PI3K/Akt reduced de novo synthesis by 75% in logarithmically growing cells. PI3K/Akt regulated early steps of de novo synthesis by modulating phosphoribosylpyrophosphate production by the non-oxidative pentose phosphate pathway and late steps by modulating activity of the bifunctional enzyme aminoimidazole-carboxamide ribonucleotide transformylase IMP cyclohydrolase, an enzyme not previously known to be regulated. The effects of PI3K/Akt on purine nucleotide salvage were likely through regulating phosphoribosylpyrophosphate availability. These studies define a new mechanism whereby the PI3K/Akt cassette functions as a master regulator of cellular metabolism and a key player in oncogenesis. | lld:pubmed |
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| pubmed-article:19068483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19068483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19068483 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19068483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19068483 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19068483 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:VighB JBJ | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:WilsonIan AIA | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:BossGerry RGR | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:PilzRenate... | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:FridmanAllaA | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:ConnellySteph... | lld:pubmed |
| pubmed-article:19068483 | pubmed:author | pubmed-author:BlackledgeWil... | lld:pubmed |
| pubmed-article:19068483 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19068483 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:19068483 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:19068483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19068483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19068483 | pubmed:pagination | 3521-8 | lld:pubmed |
| pubmed-article:19068483 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19068483 | pubmed:meshHeading | pubmed-meshheading:19068483... | lld:pubmed |
| pubmed-article:19068483 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19068483 | pubmed:articleTitle | The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. | lld:pubmed |
| pubmed-article:19068483 | pubmed:affiliation | Department of Medicine, University of California San Diego, La Jolla, California 92093, USA. | lld:pubmed |
| pubmed-article:19068483 | pubmed:publicationType | Journal Article | lld:pubmed |
