| pubmed-article:1906502 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1906502 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:1906502 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:1906502 | lifeskim:mentions | umls-concept:C1155018 | lld:lifeskim |
| pubmed-article:1906502 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:1906502 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:1906502 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1906502 | pubmed:dateCreated | 1991-8-20 | lld:pubmed |
| pubmed-article:1906502 | pubmed:abstractText | A previous report concluded that a new cytokine, designated IL-10, is a growth cofactor for thymocytes, spleen, and lymph node cells. In this report, we have focused on the effects of IL-10 on CD8+ spleen T cells. We first observed that IL-10 enhances the growth of CD8+ T cells to IL-2. We then investigated the effect of murine rIL-10 on the induction of murine effector CTL from CTL precursors (CTL-p) using both bulk and filler cell-free limiting-dilution cultures. IL-10 alone could not induce Con A-activated FACS-sorted CD8+ T cells either to proliferate or to generate effector CTL. In combination with IL-2, however, IL-10 augmented the cytolytic activity of effector CTL generated from Con A-activated spleen CD8+ T cells in bulk cultures incubated for 5 days. In limiting-dilution cultures (using solid-phase anti-CD3 mAb as stimulus), IL-10, in combination with IL-2, substantially increased the CTL-p frequency and augmented the cytolytic activity per clone expanded from one CD8+ T cell when compared with cells cultured in IL-2 alone. Kinetic studies showed that IL-10 is required at both early and late culture stages for optimal generation of effector CTL. The potentiating effects of IL-10 on CTL function were neutralized by an anti-IL-10 mAb. These results indicate that IL-10 has direct effects on mature T cells, and suggest that IL-10 also functions as a cytotoxic T cell differentiation factor, which promotes a higher number of IL-2-activated CTL-p to proliferate and differentiate into effector CTL. In contrast, IL-10 did not enhance significantly the lymphokine-activated killer cell activity of IL-2-grown CD8+ cytotoxic T cells. | lld:pubmed |
| pubmed-article:1906502 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1906502 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1906502 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1906502 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1906502 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1906502 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1906502 | pubmed:author | pubmed-author:ChenW FWF | lld:pubmed |
| pubmed-article:1906502 | pubmed:author | pubmed-author:ZlotnikAA | lld:pubmed |
| pubmed-article:1906502 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1906502 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1906502 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1906502 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1906502 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1906502 | pubmed:pagination | 528-34 | lld:pubmed |
| pubmed-article:1906502 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1906502 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1906502 | pubmed:articleTitle | IL-10: a novel cytotoxic T cell differentiation factor. | lld:pubmed |
| pubmed-article:1906502 | pubmed:affiliation | Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304. | lld:pubmed |
| pubmed-article:1906502 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1906502 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1906502 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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