| pubmed-article:19062087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C1705178 | lld:lifeskim |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C1705176 | lld:lifeskim |
| pubmed-article:19062087 | lifeskim:mentions | umls-concept:C1548602 | lld:lifeskim |
| pubmed-article:19062087 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19062087 | pubmed:dateCreated | 2008-12-16 | lld:pubmed |
| pubmed-article:19062087 | pubmed:abstractText | In normal circumstances, the Bcl-2 family dutifully governs when cells die. However, the rules of engagement between the pro- and antiapoptotic family members are still contested, and how Bax is transformed from a cytosolic monomer to an outer mitochondrial membrane-permeabilizing oligomer is unclear. With fluorescence techniques and an in vitro system, the combination of tBid and Bax produced dramatic membrane permeabilization. The membrane is not a passive partner in this process beause membranes are required for the protein-protein interactions to occur. Simultaneous measurements of these interactions revealed an ordered series of steps required for outer membrane permeabilization: (1) tBid rapidly binds to membranes, where (2) tBid interacts with Bax, causing (3) Bax insertion into membranes and (4) oligomerization, culminating in (5) membrane permeabilization. Bcl-XL prevents membrane-bound tBid from binding Bax. Bad releases tBid from Bcl-XL, restoring both tBid binding to Bax and membrane permeabilization. | lld:pubmed |
| pubmed-article:19062087 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19062087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19062087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19062087 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19062087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19062087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19062087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19062087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19062087 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19062087 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:BillenLieven... | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:AndrewsDavid... | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:LeberBrianB | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:LovellJonatha... | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:BindnerScottS | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:Shamas-DinAis... | lld:pubmed |
| pubmed-article:19062087 | pubmed:author | pubmed-author:FradinCecileC | lld:pubmed |
| pubmed-article:19062087 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19062087 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:19062087 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:19062087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19062087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19062087 | pubmed:pagination | 1074-84 | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:meshHeading | pubmed-meshheading:19062087... | lld:pubmed |
| pubmed-article:19062087 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19062087 | pubmed:articleTitle | Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. | lld:pubmed |
| pubmed-article:19062087 | pubmed:affiliation | Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. | lld:pubmed |
| pubmed-article:19062087 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19062087 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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