pubmed-article:19037922 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19037922 | lifeskim:mentions | umls-concept:C0032749 | lld:lifeskim |
pubmed-article:19037922 | lifeskim:mentions | umls-concept:C0145988 | lld:lifeskim |
pubmed-article:19037922 | lifeskim:mentions | umls-concept:C0255808 | lld:lifeskim |
pubmed-article:19037922 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
pubmed-article:19037922 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
pubmed-article:19037922 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
pubmed-article:19037922 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:19037922 | pubmed:dateCreated | 2008-11-28 | lld:pubmed |
pubmed-article:19037922 | pubmed:abstractText | Semi-quantitative RT-PCR was exploited to analyse the intralesional cytokine gene expression in 14 post-kala-azar dermal leishmaniasis (PKDL) and 10 kala-azar (KA) patients. The data provided evidence for both inflammatory and non-inflammatory responses, as reflected by elevated tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 in PKDL lesions compared with normal skin tissue (n = 6). The ratio of TNF-alpha : IL-10 message was 2.66 in PKDL cases, substantially higher than in KA (1.18). Investigation of TNF-alpha receptors (TNFR1 and TNFR2) revealed a significant down-regulation of TNFR1 transcript in both PKDL and KA compared with control. In the presence of elevated levels of TNF-alpha transcript, interference with type 1 effector activity in PKDL may be due to minimal expression of the TNFR1 gene. Investigation of matrix metalloproteinases, known to be induced by TNF-alpha, and the tissue inhibitors of matrix metalloproteinases (TIMPs), provided evidence for the roles of TIMP-1 and TIMP-3 in the pathogenesis of PKDL. | lld:pubmed |
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pubmed-article:19037922 | pubmed:language | eng | lld:pubmed |
pubmed-article:19037922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19037922 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:19037922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19037922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19037922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19037922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:19037922 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19037922 | pubmed:month | Dec | lld:pubmed |
pubmed-article:19037922 | pubmed:issn | 1365-2249 | lld:pubmed |
pubmed-article:19037922 | pubmed:author | pubmed-author:RameshVV | lld:pubmed |
pubmed-article:19037922 | pubmed:author | pubmed-author:AnsariN ANA | lld:pubmed |
pubmed-article:19037922 | pubmed:author | pubmed-author:SalotraPP | lld:pubmed |
pubmed-article:19037922 | pubmed:author | pubmed-author:KataraG KGK | lld:pubmed |
pubmed-article:19037922 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19037922 | pubmed:volume | 154 | lld:pubmed |
pubmed-article:19037922 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19037922 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19037922 | pubmed:pagination | 391-8 | lld:pubmed |
pubmed-article:19037922 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
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