| pubmed-article:19033460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:19033460 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:19033460 | pubmed:issue | 49 | lld:pubmed |
| pubmed-article:19033460 | pubmed:dateCreated | 2008-12-10 | lld:pubmed |
| pubmed-article:19033460 | pubmed:abstractText | The onset of autoimmunity in experimental rodent models and patients frequently correlates with a lymphopenic state. In this condition, the immune system has evolved compensatory homeostatic mechanisms that induce quiescent naive T cells to proliferate and differentiate into memory-like lymphocytes even in the apparent absence of antigenic stimulation. Because memory T cells have less stringent requirements for activation than naive cells, we hypothesized that autoreactive T cells that arrive to secondary lymphoid organs in a lymphopenic environment could differentiate and bypass the mechanisms of peripheral tolerance such as those mediated by self-antigen cross-presentation. Here, we show that lymphopenia-driven proliferation and differentiation of potentially autoreactive CD8(+) T cells into memory-like cells is not sufficient to induce self-reactivity against a pancreatic antigen. Induction of an organ-specific autoimmunity required antigen-specific CD4(+) T cell help. Notably, we found that this function could be accomplished by memory-like CD4(+) T cells generated in vivo through lymphopenia-induced proliferation. These helper cells promoted the further differentiation of memory-like CD8(+) T cells into effectors in response to antigen cross-presentation, resulting in their migration to the tissue of antigen expression where autoimmunity ensued. Thus, the cooperation of self-reactive memory-like CD4(+) and CD8(+) T cells under lymphopenic conditions overcomes cross-tolerance resulting in autoimmunity. | lld:pubmed |
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| pubmed-article:19033460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19033460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19033460 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19033460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19033460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19033460 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19033460 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19033460 | pubmed:author | pubmed-author:TaylorNaomiN | lld:pubmed |
| pubmed-article:19033460 | pubmed:author | pubmed-author:HernandezJavi... | lld:pubmed |
| pubmed-article:19033460 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:19033460 | pubmed:author | pubmed-author:MennechetSand... | lld:pubmed |
| pubmed-article:19033460 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19033460 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:19033460 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:19033460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19033460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19033460 | pubmed:pagination | 19414-9 | lld:pubmed |
| pubmed-article:19033460 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19033460 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19033460 | pubmed:articleTitle | Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions. | lld:pubmed |
