| pubmed-article:19016589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0027361 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C2699549 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0005885 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0917713 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0339510 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0018684 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C1414083 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C1826421 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0177804 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:19016589 | lifeskim:mentions | umls-concept:C0683712 | lld:lifeskim |
| pubmed-article:19016589 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19016589 | pubmed:dateCreated | 2009-3-5 | lld:pubmed |
| pubmed-article:19016589 | pubmed:abstractText | Fetuin-A is a hepatic secretory protein that promotes bone mineralization in vitro. Whether fetuin-A levels are associated with BMD in humans is unknown. The Health Aging and Body Composition study enrolled 3075 well-functioning black and white persons 70-79 yr of age and measured BMD. This cross-sectional study measured serum fetuin-A using ELISA among a random sample of 508 participants within sex and race strata. Multivariate linear regression analysis evaluated the associations of fetuin-A with BMD. Among women (n = 257), higher fetuin-A levels were significantly associated with higher total hip (p = 0.02), lumbar spine (p = 0.03), and whole body BMD (p = 0.01) in models adjusted for age, race, diabetes, alcohol and tobacco use, physical activity, body mass index, C-reactive protein levels, calcium supplement, and estrogen use. For example, each SD (0.38 g/liter) higher level of fetuin-A was associated with 0.016 g/cm(2) higher total hip areal BMD. The association was of similar magnitude and direction for femoral neck BMD but did not reach statistical significance (p = 0.11). In contrast, among men (n = 251), fetuin-A had no significant associations with total hip (p = 0.79), lumbar spine (p = 0.35), whole body (p = 0.46), or femoral neck BMD (p = 0.54) in multivariable models. We conclude that higher fetuin-A levels are independently associated with higher BMD among well-functioning community-dwelling older women but not older men. Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women. | lld:pubmed |
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| pubmed-article:19016589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19016589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19016589 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19016589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19016589 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19016589 | pubmed:issn | 1523-4681 | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:Health ABC... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:PricePaul APA | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:HarrisTamara... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:CauleyJane... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:CummingsSteve... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:BauerDouglas... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:IxJoachim HJH | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:ShlipakMichae... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:TylavskyFranc... | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:ToroianDamonD | lld:pubmed |
| pubmed-article:19016589 | pubmed:author | pubmed-author:WasselChristi... | lld:pubmed |
| pubmed-article:19016589 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19016589 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:19016589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19016589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19016589 | pubmed:pagination | 514-21 | lld:pubmed |
| pubmed-article:19016589 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
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| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:meshHeading | pubmed-meshheading:19016589... | lld:pubmed |
| pubmed-article:19016589 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19016589 | pubmed:articleTitle | Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) study. | lld:pubmed |
| pubmed-article:19016589 | pubmed:affiliation | Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA. joeix@ucsd.edu | lld:pubmed |
| pubmed-article:19016589 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19016589 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19016589 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:19016589 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
