| pubmed-article:18982194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18982194 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18982194 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:18982194 | lifeskim:mentions | umls-concept:C0600431 | lld:lifeskim |
| pubmed-article:18982194 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18982194 | pubmed:dateCreated | 2009-2-16 | lld:pubmed |
| pubmed-article:18982194 | pubmed:abstractText | Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation. | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18982194 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18982194 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18982194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18982194 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18982194 | pubmed:issn | 1414-431X | lld:pubmed |
| pubmed-article:18982194 | pubmed:author | pubmed-author:RodriguesM... | lld:pubmed |
| pubmed-article:18982194 | pubmed:author | pubmed-author:NathansonM... | lld:pubmed |
| pubmed-article:18982194 | pubmed:author | pubmed-author:GomesD ADA | lld:pubmed |
| pubmed-article:18982194 | pubmed:author | pubmed-author:LeiteM FMF | lld:pubmed |
| pubmed-article:18982194 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18982194 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:18982194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18982194 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18982194 | pubmed:pagination | 17-20 | lld:pubmed |
| pubmed-article:18982194 | pubmed:dateRevised | 2011-3-8 | lld:pubmed |
| pubmed-article:18982194 | pubmed:meshHeading | pubmed-meshheading:18982194... | lld:pubmed |
| pubmed-article:18982194 | pubmed:meshHeading | pubmed-meshheading:18982194... | lld:pubmed |
| pubmed-article:18982194 | pubmed:meshHeading | pubmed-meshheading:18982194... | lld:pubmed |
| pubmed-article:18982194 | pubmed:meshHeading | pubmed-meshheading:18982194... | lld:pubmed |
| pubmed-article:18982194 | pubmed:meshHeading | pubmed-meshheading:18982194... | lld:pubmed |
| pubmed-article:18982194 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18982194 | pubmed:articleTitle | Nuclear calcium signaling: a cell within a cell. | lld:pubmed |
| pubmed-article:18982194 | pubmed:affiliation | Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. | lld:pubmed |
| pubmed-article:18982194 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18982194 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:18982194 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18982194 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18982194 | lld:pubmed |
