| pubmed-article:18955504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C0812201 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C0919496 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C1334468 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C1449575 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18955504 | lifeskim:mentions | umls-concept:C1328856 | lld:lifeskim |
| pubmed-article:18955504 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18955504 | pubmed:dateCreated | 2008-12-16 | lld:pubmed |
| pubmed-article:18955504 | pubmed:abstractText | The Smad2 and Smad3 (Smad2/3) proteins are principally involved in the transmission of transforming growth factor beta (TGF-beta) signaling from the plasma membrane to the nucleus. Many transcription factors have been shown to cooperate with the Smad2/3 proteins in regulating the transcription of target genes, enabling appropriate gene expression by cells. Here we identified 1,787 Smad2/3 binding sites in the promoter regions of over 25,500 genes by chromatin immunoprecipitation on microarray in HaCaT keratinocytes. Binding elements for the v-ets erythroblastosis virus E26 oncogene homolog (ETS) and transcription factor AP-2 (TFAP2) were significantly enriched in Smad2/3 binding sites, and knockdown of either ETS1 or TFAP2A resulted in overall alteration of TGF-beta-induced transcription, suggesting general roles for ETS1 and TFAP2A in the transcription induced by TGF-beta-Smad pathways. We identified novel Smad binding sites in the CDKN1A gene where Smad2/3 binding was regulated by ETS1 and TFAP2A. Moreover, we showed that small interfering RNAs for ETS1 and TFAP2A affected TGF-beta-induced cytostasis. We also analyzed Smad2- or Smad3-specific target genes regulated by TGF-beta and found that their specificity did not appear to be solely determined by the amounts of the Smad2/3 proteins bound to the promoters. These findings reveal novel regulatory mechanisms of Smad2/3-induced transcription and provide an essential resource for understanding their roles. | lld:pubmed |
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| pubmed-article:18955504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18955504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18955504 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18955504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18955504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18955504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18955504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18955504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18955504 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18955504 | pubmed:issn | 1098-5549 | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:MiyazonoKohei... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:MiyazawaKeiji... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:TaniguchiHiro... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:TsutsumiShuic... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:AburataniHiro... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:KoinumaDaizoD | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:ImamuraTakesh... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:SunamuraMakot... | lld:pubmed |
| pubmed-article:18955504 | pubmed:author | pubmed-author:KamimuraNaoko... | lld:pubmed |
| pubmed-article:18955504 | pubmed:issnType | Electronic | lld:pubmed |
