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pubmed-article:18923538pubmed:dateCreated2008-10-16lld:pubmed
pubmed-article:18923538pubmed:abstractTextThe silent X chromosome in mammalian females is a classic example of facultative heterochromatin, the term highlighting the compacted and inactive nature of the chromosome. However, it is now clear that the heterochromatin of the inactive X is not homogeneous--as indeed, not all genes on the inactive X are silenced. We summarize known features and events of X inactivation in different mouse and human model systems, and highlight the heterogeneity of chromatin along the inactive X. Characterizing this heterogeneity is likely to provide insight into the cis-acting sequences involved in X chromosome inactivation.lld:pubmed
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pubmed-article:18923538pubmed:dateRevised2009-5-7lld:pubmed
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pubmed-article:18923538pubmed:articleTitleX chromosome inactivation: heterogeneity of heterochromatin.lld:pubmed
pubmed-article:18923538pubmed:affiliationMolecular Epigenetics Group, Department of Medical Genetics, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.lld:pubmed
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