| pubmed-article:1892275 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1892275 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:1892275 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:1892275 | lifeskim:mentions | umls-concept:C0324336 | lld:lifeskim |
| pubmed-article:1892275 | lifeskim:mentions | umls-concept:C0302332 | lld:lifeskim |
| pubmed-article:1892275 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1892275 | lifeskim:mentions | umls-concept:C0212021 | lld:lifeskim |
| pubmed-article:1892275 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1892275 | pubmed:dateCreated | 1991-10-17 | lld:pubmed |
| pubmed-article:1892275 | pubmed:abstractText | Fifteen Collies, previously having mild reactions to ivermectin challenge (120 micrograms/kg of body weight; 20 times the recommended dosage level), were studied to evaluate the effects of milbemycin oxime administration at 5 and 10 mg/kg (10 and 20 times the manufacturer's recommended dosage). Five replicates, comprising 3 dogs each, were formed on the basis of body weight. Within replicates, each dog was randomly allocated to treatment with 5 or 10 mg of milbemycin/kg or served as a untreated control. Dogs were examined repeatedly for signs of toxicosis for 4 days after treatment and daily thereafter. Two of 5 dogs treated at 5 mg/kg (10x) developed signs of mild depression on the day of treatment, but were normal 24 hours after treatment. All 5 dogs treated at 10 mg/kg (20x) developed signs of mild depression and ataxia by 6 hours. Signs persisted for 24 hours in 3 dogs. Two of these dogs also had mydriasis, whereas 3 salivated excessively. All dogs recovered completely by day 2 after treatment. The results of this study demonstrated that Collies sensitive to the effects of 120 micrograms of ivermectin (20x)/kg show similar sensitivity to the effects of milbemycin oxine administered at 10 mg/kg (20x). We conclude that ivermectin and milbemycin commercial formulations have similar margins of safety and that milbemycin toxicosis appears to be dose-dependent in Collies with a demonstrated sensitivity to ivermectin. | lld:pubmed |
| pubmed-article:1892275 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1892275 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1892275 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1892275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1892275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1892275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1892275 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1892275 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1892275 | pubmed:issn | 0002-9645 | lld:pubmed |
| pubmed-article:1892275 | pubmed:author | pubmed-author:ToddK SKS | lld:pubmed |
| pubmed-article:1892275 | pubmed:author | pubmed-author:TranquilliW... | lld:pubmed |
| pubmed-article:1892275 | pubmed:author | pubmed-author:PaulA JAJ | lld:pubmed |
| pubmed-article:1892275 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1892275 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:1892275 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1892275 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1892275 | pubmed:pagination | 1170-2 | lld:pubmed |
| pubmed-article:1892275 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:meshHeading | pubmed-meshheading:1892275-... | lld:pubmed |
| pubmed-article:1892275 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1892275 | pubmed:articleTitle | Assessment of toxicosis induced by high-dose administration of milbemycin oxime in collies. | lld:pubmed |
| pubmed-article:1892275 | pubmed:affiliation | Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801. | lld:pubmed |
| pubmed-article:1892275 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1892275 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1892275 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1892275 | lld:pubmed |
