| pubmed-article:18855265 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C1412113 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0680242 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:18855265 | lifeskim:mentions | umls-concept:C1958507 | lld:lifeskim |
| pubmed-article:18855265 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18855265 | pubmed:dateCreated | 2008-10-15 | lld:pubmed |
| pubmed-article:18855265 | pubmed:abstractText | Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2(*-) balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2(*-) balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT(1)) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2(*-) production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2(*-). These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT(1) receptor antagonism. | lld:pubmed |
| pubmed-article:18855265 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18855265 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18855265 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18855265 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18855265 | pubmed:issn | 1525-6006 | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:LüscherThomas... | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:ShawSidneyS | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:VolpeMassimoM | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:CosentinoFran... | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:EtoMasatoM | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:KouroedovAlex... | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:Delli... | lld:pubmed |
| pubmed-article:18855265 | pubmed:author | pubmed-author:OstoElenaE | lld:pubmed |
| pubmed-article:18855265 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18855265 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:18855265 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18855265 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18855265 | pubmed:pagination | 616-27 | lld:pubmed |
| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
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| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
| pubmed-article:18855265 | pubmed:meshHeading | pubmed-meshheading:18855265... | lld:pubmed |
| pubmed-article:18855265 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18855265 | pubmed:articleTitle | Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism. | lld:pubmed |
| pubmed-article:18855265 | pubmed:affiliation | Cardiovascular Center, University Hospital and Cardiovascular Research, Institute of Physiology, Zurich, Switzerland. | lld:pubmed |
| pubmed-article:18855265 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18855265 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
