| pubmed-article:18854239 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C0032064 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C0768454 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:18854239 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:18854239 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18854239 | pubmed:dateCreated | 2008-10-15 | lld:pubmed |
| pubmed-article:18854239 | pubmed:abstractText | Educating dendritic cells (DC) to become tolerogenic DC, which promote regulatory IL-10 immune responses, represents an effective immune evasion strategy for pathogens. Yersinia pestis virulence factor LcrV is reported to induce IL-10 production via interaction with Toll-like receptor (TLR) 2. However, TLR2-/- mice are not protected against subcutaneous plague infection. Using complementary in vitro and in vivo approaches and LcrV as a model, we show that TLR6 associates with TLR2 to induce tolerogenic DC and regulatory type-1 T cells selectively secreting IL-10. In contrast, TLR1 heterodimerizes with TLR2 to promote proinflammatory IL-12p40 cytokine, producing DC and inflammatory T cell differentiation. LcrV specifically hijacks the TLR2/6 pathway to stimulate IL-10 production, which blocks host protective inflammatory responses. These results explain why TLR2 can mediate both pro- and anti-inflammatory responses and identify TLR6 as a distinct receptor driving regulatory IL-10 responses. | lld:pubmed |
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| pubmed-article:18854239 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18854239 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18854239 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18854239 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18854239 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18854239 | pubmed:issn | 1934-6069 | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:LinK JKJ | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:SchneewindOla... | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:LinAnningA | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:CilettiNancyN | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:JabriBanaB | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:KimInyoungI | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:AndersonDebra... | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:TangFangmingF | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:DepaoloR... | lld:pubmed |
| pubmed-article:18854239 | pubmed:author | pubmed-author:LevinNadineN | lld:pubmed |
| pubmed-article:18854239 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18854239 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:18854239 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:18854239 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18854239 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18854239 | pubmed:pagination | 350-61 | lld:pubmed |
| pubmed-article:18854239 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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