| pubmed-article:18852898 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C0162741 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C1820370 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C0083956 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:18852898 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:18852898 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18852898 | pubmed:dateCreated | 2008-10-14 | lld:pubmed |
| pubmed-article:18852898 | pubmed:abstractText | Polycomb group (PcG) proteins are evolutionarily conserved in animals and plants, and play critical roles in the regulation of developmental gene expression. Here we show that the Arabidopsis Polycomb repressive complex 2 (PRC2) subunits CURLY LEAF (CLF), EMBRYONIC FLOWER 2 (EMF2) and FERTILIZATION INDEPENDENT ENDOSPERM (FIE) repress the expression of FLOWERING LOCUS C (FLC), a central repressor of the floral transition in Arabidopsis and FLC relatives. In addition, CLF directly interacts with and mediates the deposition of repressive histone H3 lysine 27 trimethylation (H3K27me3) into FLC and FLC relatives, which suppresses active histone H3 lysine 4 trimethylation (H3K4me3) in these loci. Furthermore, we show that during vegetative development CLF and FIE strongly repress the expression of FLOWERING LOCUS T (FT), a key flowering-time integrator, and that CLF also directly interacts with and mediates the deposition of H3K27me3 into FT chromatin. Our results suggest that PRC2-like complexes containing CLF, EMF2 and FIE, directly interact with and deposit into FT, FLC and FLC relatives repressive trimethyl H3K27 leading to the suppression of active H3K4me3 in these loci, and thus repress the expression of these flowering genes. Given the central roles of FLC and FT in flowering-time regulation in Arabidopsis, these findings suggest that the CLF-containing PRC2-like complexes play a significant role in control of flowering in Arabidopsis. | lld:pubmed |
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| pubmed-article:18852898 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18852898 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18852898 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18852898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18852898 | pubmed:status | MEDLINE | lld:pubmed |
