| pubmed-article:18790444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18790444 | lifeskim:mentions | umls-concept:C0021083 | lld:lifeskim |
| pubmed-article:18790444 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:18790444 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18790444 | pubmed:dateCreated | 2008-9-15 | lld:pubmed |
| pubmed-article:18790444 | pubmed:abstractText | Immunotherapy for B-cell chronic lymphocytic leukaemia (B-CLL) and other haematological malignancies may consist of passive antibody, active immunization or adoptive T-cell transfer. This chapter will focus on T-lymphocyte immunotherapy; an approach supported by earlier observations that the beneficial effects of allogeneic stem cell transplantation depend, in part, on the graft-versus-leukaemia effects mediated by these cells. One promising strategy consists of the genetic manipulation of effector T lymphocytes to express tumour-specific T-cell receptors or chimeric antigen receptors directed against surface antigens on the B-CLL cells. This methodology is now being integrated with the concept that tumour recurrence may be due to the persistence of a reservoir of more primitive and chemoresistant tumour cells, dubbed 'cancer stem cells', with self-renewal capacity. Identification and characterization of these cancer stem cells in B-CLL is crucial for the development of new anti-tumour agents, and for the identification of target antigens for cellular immunotherapy. This chapter will describe how immunotherapy may be directed to a more primitive side population of B-CLL cells. | lld:pubmed |
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| pubmed-article:18790444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18790444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18790444 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18790444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18790444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18790444 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18790444 | pubmed:issn | 1521-6926 | lld:pubmed |
| pubmed-article:18790444 | pubmed:author | pubmed-author:BrennerMalcol... | lld:pubmed |
| pubmed-article:18790444 | pubmed:author | pubmed-author:DottiGianpiet... | lld:pubmed |
| pubmed-article:18790444 | pubmed:author | pubmed-author:FosterAaron... | lld:pubmed |
| pubmed-article:18790444 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18790444 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:18790444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18790444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18790444 | pubmed:pagination | 375-89 | lld:pubmed |
