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pubmed-article:18778936pubmed:abstractTextA novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. Starting from a 3.4 microM high throughput screen hit, members of this series have been identified which are full agonists with functional potency <50 nM and oral bioavailability in mice.lld:pubmed
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pubmed-article:18778936pubmed:articleTitleDiscovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.lld:pubmed
pubmed-article:18778936pubmed:affiliationGenomics Institute of the Novartis Research Foundation (GNF), San Diego, CA 92121, USA.lld:pubmed
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