Linked Life Data

18768977

Source:http://linkedlifedata.com/resource/pubmed/id/18768977

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pubmed-article:18768977pubmed:abstractTextCD4 T cells are not essential for primary clearance of replicating murine gammaherpesvirus 68 (MHV-68) but are required for effective long-term control. The virus reactivates in the lungs of major histocompatibility complex class II-deficient (CII-/-) mice that lack functional CD4 T cells. CD40 ligand (CD40L) is upregulated on activated CD4 T cells, and it is thought that CD40-CD40L interactions are an important component of CD4 T-cell help. Our previous studies have shown that agonistic antibodies to CD40 can substitute for CD4 T-cell function in the long-term control of MHV-68. In the present study, we sought to identify the CD40-positive cell type mediating this effect. To address this question, we adoptively transferred MHV-68 peptide-pulsed CII(-/-) dendritic cells (DC) that had been treated with an agonistic antibody to CD40 into MHV-68-infected CII(-/-) recipients. Viral reactivation was significantly lower in mice injected with anti-CD40-treated DC than in those injected with control DC or in mice that did not receive any DC. However, in similar experiments with B cells, anti-CD40 treatment had no effect. We also investigated the requirement for CD40 expression on T cells by adoptive transfer of T cells from CD40(+/+) or CD40(-/-) mice into T-cell-deficient recipients that were subsequently infected with MHV-68. The results showed that CD40 expression on T cells is not necessary for preventing viral reactivation. Taken together, our data suggest that CD40 engagement on DC, but not on T or B cells, is essential for effective long-term control of MHV-68.lld:pubmed
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pubmed-article:18768977pubmed:authorpubmed-author:SarawarSally...lld:pubmed
pubmed-article:18768977pubmed:authorpubmed-author:GiannoniFranc...lld:pubmed
pubmed-article:18768977pubmed:authorpubmed-author:LeeLian NiLNlld:pubmed
pubmed-article:18768977pubmed:authorpubmed-author:InglisChandra...lld:pubmed
pubmed-article:18768977pubmed:authorpubmed-author:SheaAshleyAlld:pubmed
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pubmed-article:18768977pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:18768977pubmed:articleTitleCD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68.lld:pubmed
pubmed-article:18768977pubmed:affiliationViral Immunology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA. ssarawar@tpims.orglld:pubmed
pubmed-article:18768977pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18768977pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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