| pubmed-article:18755897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18755897 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:18755897 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:18755897 | lifeskim:mentions | umls-concept:C1423062 | lld:lifeskim |
| pubmed-article:18755897 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18755897 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:18755897 | pubmed:dateCreated | 2008-9-10 | lld:pubmed |
| pubmed-article:18755897 | pubmed:abstractText | MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation is not completely understood. We now show that the microRNA miR-34a regulates silent information regulator 1 (SIRT1) expression. MiR-34a inhibits SIRT1 expression through a miR-34a-binding site within the 3' UTR of SIRT1. MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. Furthermore, miR-34 suppression of SIRT1 ultimately leads to apoptosis in WT human colon cancer cells but not in human colon cancer cells lacking p53. Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway. | lld:pubmed |
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| pubmed-article:18755897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18755897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18755897 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18755897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18755897 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18755897 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:18755897 | pubmed:author | pubmed-author:LowensteinCha... | lld:pubmed |
| pubmed-article:18755897 | pubmed:author | pubmed-author:YamakuchiMune... | lld:pubmed |
| pubmed-article:18755897 | pubmed:author | pubmed-author:FerlitoMarcel... | lld:pubmed |
| pubmed-article:18755897 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18755897 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:18755897 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:18755897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18755897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18755897 | pubmed:pagination | 13421-6 | lld:pubmed |
| pubmed-article:18755897 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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