| pubmed-article:1875349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1875349 | lifeskim:mentions | umls-concept:C1998062 | lld:lifeskim |
| pubmed-article:1875349 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:1875349 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:1875349 | lifeskim:mentions | umls-concept:C0045868 | lld:lifeskim |
| pubmed-article:1875349 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1875349 | pubmed:dateCreated | 1991-9-25 | lld:pubmed |
| pubmed-article:1875349 | pubmed:abstractText | A wide variety of 2-substituted aminoadenosines were prepared for comparison with the moderately A2 receptor selective adenosine agonist 2-anilinoadenosine (CV-1808). High selectivity combined with significant affinity at the A2 receptor in rat membranes was observed for those amines bearing a two-carbon chain to which was attached an aryl, heteroaryl, or alicyclic moiety. 2-(2-Phenethylamino)adenosine (3d), a 14-fold A2 selective compound, was modified by introduction of a variety of substituents in the benzene ring and the side chain. Some of these changes led to improved A2 affinity and increased selectivity. Replacement of the phenyl moiety by cyclohexenyl produced a 210-fold selective agonist 3ag (CGS 22989) whereas the cyclohexanyl analogue 3af (CGS 22492) was 530-fold selective at the A2 site. These compounds showed hypotensive activity in rat models over a range of doses without the bradycardia observed with less selective agonists. | lld:pubmed |
| pubmed-article:1875349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1875349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1875349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1875349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1875349 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1875349 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:YokoyamaRR | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:FrancisJ EJE | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:DotsonRR | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:VEISII | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:HutchisonA... | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:ContardoNN | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:RovinskiS LSL | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:deJesusRR | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:GhaiG RGR | lld:pubmed |
| pubmed-article:1875349 | pubmed:author | pubmed-author:MoskalM AMA | lld:pubmed |
| pubmed-article:1875349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1875349 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:1875349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1875349 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1875349 | pubmed:pagination | 2570-9 | lld:pubmed |
| pubmed-article:1875349 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:meshHeading | pubmed-meshheading:1875349-... | lld:pubmed |
| pubmed-article:1875349 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1875349 | pubmed:articleTitle | Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines. | lld:pubmed |
| pubmed-article:1875349 | pubmed:affiliation | Research Department, CIBA-GEIGY Corporation, Summit, New Jersey 07901. | lld:pubmed |
| pubmed-article:1875349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1875349 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:1875349 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1875349 | lld:pubmed |
