Linked Life Data

18728729

Source:http://linkedlifedata.com/resource/pubmed/id/18728729

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18728729rdf:typepubmed:Citationlld:pubmed
pubmed-article:18728729lifeskim:mentionsumls-concept:C0007600lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C0039194lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C0162638lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C0332157lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C1523924lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:18728729lifeskim:mentionsumls-concept:C0054041lld:lifeskim
pubmed-article:18728729pubmed:issue2lld:pubmed
pubmed-article:18728729pubmed:dateCreated2008-8-27lld:pubmed
pubmed-article:18728729pubmed:abstractTextHarmful algal blooms (HABs) of the toxic dinoflagellate, Karenia brevis, produce red tide toxins, or brevetoxins. Significant health effects associated with red tide toxin exposure have been reported in sea life and in humans, with brevetoxins documented within immune cells from many species. The objective of this research was to investigate potential immunotoxic effects of brevetoxins using a leukemic T cell line (Jurkat) as an in vitro model system. Viability, cell proliferation, and apoptosis assays were conducted using brevetoxin congeners PbTx-2, PbTx-3, and PbTx-6. The effects of in vitro brevetoxin exposure on cell viability and cellular metabolism or proliferation were determined using trypan blue and MTT (1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan), respectively. Using MTT, cellular metabolic activity was decreased in Jurkat cells exposed to 5 - 10 microg/ml PbTx-2 or PbTx-6. After 3 h, no significant effects on cell viability were observed with any toxin congener in concentrations up to 10 microg/ml. Viability decreased dramatically after 24 h in cells treated with PbTx-2 or -6. Apoptosis, as measured by caspase-3 activity, was significantly increased in cells exposed to PbTx-2 or PbTx-6. In summary, brevetoxin congeners varied in effects on Jurkat cells, with PbTx-2 and PbTx-6 eliciting greater cellular effects compared to PbTx-3.lld:pubmed
pubmed-article:18728729pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:languageenglld:pubmed
pubmed-article:18728729pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:citationSubsetIMlld:pubmed
pubmed-article:18728729pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728729pubmed:statusMEDLINElld:pubmed
pubmed-article:18728729pubmed:issn1660-3397lld:pubmed
pubmed-article:18728729pubmed:authorpubmed-author:WalshCatherin...lld:pubmed
pubmed-article:18728729pubmed:authorpubmed-author:SleasmanJohn...lld:pubmed
pubmed-article:18728729pubmed:authorpubmed-author:PierceRichard...lld:pubmed
pubmed-article:18728729pubmed:authorpubmed-author:LeggettStepha...lld:pubmed
pubmed-article:18728729pubmed:authorpubmed-author:StrohbehnKath...lld:pubmed
pubmed-article:18728729pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18728729pubmed:volume6lld:pubmed
pubmed-article:18728729pubmed:ownerNLMlld:pubmed
pubmed-article:18728729pubmed:authorsCompleteYlld:pubmed
pubmed-article:18728729pubmed:pagination291-307lld:pubmed
pubmed-article:18728729pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:meshHeadingpubmed-meshheading:18728729...lld:pubmed
pubmed-article:18728729pubmed:year2008lld:pubmed
pubmed-article:18728729pubmed:articleTitleEffects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat).lld:pubmed
pubmed-article:18728729pubmed:affiliationMarine Immunology Program, Center for Shark Research, Mote Marine Laboratory, Sarasota, FL 34236, USA. cjwalsh@mote.orglld:pubmed
pubmed-article:18728729pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18728729pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:18728729pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18728729lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18728729lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18728729lld:pubmed