| pubmed-article:18724381 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C0031330 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C2348199 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:18724381 | lifeskim:mentions | umls-concept:C0360703 | lld:lifeskim |
| pubmed-article:18724381 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18724381 | pubmed:dateCreated | 2008-11-12 | lld:pubmed |
| pubmed-article:18724381 | pubmed:abstractText | The short QT syndrome (SQTS) is associated with cardiac arrhythmias and sudden death. The SQT1 form of SQTS results from an inactivation-attenuated, gain-of-function mutation (N588K) to the human ether-à-go-go-related gene (hERG) potassium channel. Pharmacological blockade of this mutated hERG channel may have therapeutic value. However, hERG-blocking potencies of canonical inhibitors such as E-4031 and D-sotalol are significantly reduced for N588K-hERG. Here, five hERG-blocking drugs were compared to determine their relative potencies for inhibiting N588K channels, and two other inactivation-attenuated mutant channels were tested to investigate the association between impaired inactivation and altered drug potency. | lld:pubmed |
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| pubmed-article:18724381 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18724381 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18724381 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18724381 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18724381 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18724381 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18724381 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18724381 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18724381 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18724381 | pubmed:issn | 1476-5381 | lld:pubmed |
| pubmed-article:18724381 | pubmed:author | pubmed-author:WitchelH JHJ | lld:pubmed |
| pubmed-article:18724381 | pubmed:author | pubmed-author:DuncanR SRS | lld:pubmed |
| pubmed-article:18724381 | pubmed:author | pubmed-author:HancoxJ CJC | lld:pubmed |
| pubmed-article:18724381 | pubmed:author | pubmed-author:McPateM JMJ | lld:pubmed |
| pubmed-article:18724381 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18724381 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:18724381 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18724381 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18724381 | pubmed:pagination | 957-66 | lld:pubmed |
| pubmed-article:18724381 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:meshHeading | pubmed-meshheading:18724381... | lld:pubmed |
| pubmed-article:18724381 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18724381 | pubmed:articleTitle | Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. | lld:pubmed |
| pubmed-article:18724381 | pubmed:affiliation | Cardiovascular Research Laboratories, Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK. | lld:pubmed |
| pubmed-article:18724381 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18724381 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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