| pubmed-article:18689548 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18689548 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18689548 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:18689548 | lifeskim:mentions | umls-concept:C0966897 | lld:lifeskim |
| pubmed-article:18689548 | lifeskim:mentions | umls-concept:C0020980 | lld:lifeskim |
| pubmed-article:18689548 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18689548 | pubmed:dateCreated | 2008-11-7 | lld:pubmed |
| pubmed-article:18689548 | pubmed:abstractText | We developed and validated the first serum enzyme-linked immunosorbent assay for hepcidin, the principal iron-regulatory hormone that has been very difficult to measure. In healthy volunteers, the 5% to 95% range of hepcidin concentrations was 29 to 254 ng/mL in men (n = 65) and 17 to 286 ng/mL in women (n = 49), with median concentrations 112 versus 65 (P < .001). The lower limit of detection was 5 ng/mL. Serum hepcidin concentrations in 24 healthy subjects correlated well with their urinary hepcidin (r = 0.82). Serum hepcidin appropriately correlated with serum ferritin (r = 0.63), reflecting the regulation of both proteins by iron stores. Healthy volunteers showed a diurnal increase of serum hepcidin at noon and 8 pm compared with 8 am, and a transient rise of serum hepcidin in response to iron ingestion. Expected alterations in hepcidin levels were observed in a variety of clinical conditions associated with iron disturbances. Serum hepcidin concentrations were undetectable or low in patients with iron deficiency anemia (ferritin < 10 ng/mL), iron-depleted HFE hemochromatosis, and juvenile hemochromatosis. Serum hepcidin concentrations were high in patients with inflammation (C-reactive protein > 10 mg/dL), multiple myeloma, or chronic kidney disease. The new serum hepcidin enzyme-linked immunosorbent assay yields accurate and reproducible measurements that appropriately reflect physiologic, pathologic, and genetic influences, and is informative about the etiology of iron disorders. | lld:pubmed |
| pubmed-article:18689548 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18689548 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18689548 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18689548 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18689548 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18689548 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18689548 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:18689548 | pubmed:author | pubmed-author:GanzTomasT | lld:pubmed |
| pubmed-article:18689548 | pubmed:author | pubmed-author:GirelliDomeni... | lld:pubmed |
| pubmed-article:18689548 | pubmed:author | pubmed-author:NemethElizabe... | lld:pubmed |
| pubmed-article:18689548 | pubmed:author | pubmed-author:OlbinaGordana... | lld:pubmed |
| pubmed-article:18689548 | pubmed:author | pubmed-author:WestermanMark... | lld:pubmed |
| pubmed-article:18689548 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18689548 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18689548 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:18689548 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18689548 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18689548 | pubmed:pagination | 4292-7 | lld:pubmed |
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| pubmed-article:18689548 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18689548 | pubmed:articleTitle | Immunoassay for human serum hepcidin. | lld:pubmed |
| pubmed-article:18689548 | pubmed:affiliation | Intrinsic LifeSciences LLC, La Jolla, CA, USA. tganz@mednet.ucla.edu | lld:pubmed |
| pubmed-article:18689548 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18689548 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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