| pubmed-article:18684826 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C0205725 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C1504389 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18684826 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:18684826 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:18684826 | pubmed:dateCreated | 2008-9-30 | lld:pubmed |
| pubmed-article:18684826 | pubmed:abstractText | Recovery of human cytomegalovirus (HCMV)-specific T immunity is critical for protection against HCMV disease in the early phase after allogeneic stem cell transplantation (SCT). Using an enzyme-linked immunospot assay with overlapping 15-mer peptides spanning pp65 and immediate-early 1 HCMV proteins, we investigated which HCMV-specific CD8(+) gamma interferon-positive (IFN-gamma(+)) T-cell responses against pp65 and IE-1 were associated with control of HCMV replication in 48 recipients of unmanipulated HLA-matched allografts at 3 months (M3) and 6 months (M6) after SCT and in 23 donors. At M3 after SCT, the magnitude of the pp65-specific IFN-gamma-producing CD8(+) T-cell response was greater in recipients than in donors, regardless of HCMV status. In contrast, expansion of IE-1-specific CD8(+) T cells at M3 was associated with protection against HCMV, and no patient with this expansion had HCMV replication at M3. At M6, the number of HCMV-specific CD8(+) T cells against both pp65 and IE-1 had expanded in all recipients, regardless of their previous levels of HCMV replication. The recipients' HCMV-specific CD8(+) T cells already detectable in related donors were predominantly targeting pp65. In contrast, in 40% of the cases, the HCMV-specific CD8(+) T cells in recipients involved new CD8(+) T-cell specificities undetectable in their related donors and preferentially targeting IE-1. Taken together, these results showed that the delay in reconstituting IE-1-specific CD8(+) T cells is correlated with the lack of protection against HCMV in the first 3 months after SCT. They also show that IE-1 is a major antigenic determinant of the early restoration of protective immunity to HCMV after SCT. | lld:pubmed |
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| pubmed-article:18684826 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18684826 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684826 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18684826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684826 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18684826 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18684826 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:DhedinNathali... | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:VernantJean-P... | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:LeblondVéroni... | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:AutranBrigitt... | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:CarcelainGuis... | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:NguyenStéphan... | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:SacreKarimK | lld:pubmed |
| pubmed-article:18684826 | pubmed:author | pubmed-author:DebackClaireC | lld:pubmed |
| pubmed-article:18684826 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18684826 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:18684826 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18684826 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18684826 | pubmed:pagination | 10143-52 | lld:pubmed |
| pubmed-article:18684826 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18684826 | pubmed:meshHeading | pubmed-meshheading:18684826... | lld:pubmed |
| pubmed-article:18684826 | pubmed:meshHeading | pubmed-meshheading:18684826... | lld:pubmed |
| pubmed-article:18684826 | pubmed:meshHeading | pubmed-meshheading:18684826... | lld:pubmed |
| pubmed-article:18684826 | pubmed:meshHeading | pubmed-meshheading:18684826... | lld:pubmed |
| pubmed-article:18684826 | pubmed:meshHeading | pubmed-meshheading:18684826... | lld:pubmed |
| pubmed-article:18684826 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18684826 | pubmed:articleTitle | Expansion of human cytomegalovirus (HCMV) immediate-early 1-specific CD8+ T cells and control of HCMV replication after allogeneic stem cell transplantation. | lld:pubmed |
| pubmed-article:18684826 | pubmed:affiliation | Laboratoire d'Immunologie Cellulaire et Tissulaire, INSERM U543, Hôpital Pitié-Salpêtrière, 83 Bld de l'Hôpital, 75651 Paris Cedex 13, France. | lld:pubmed |
| pubmed-article:18684826 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18684826 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
