| pubmed-article:18675275 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18675275 | lifeskim:mentions | umls-concept:C0600327 | lld:lifeskim |
| pubmed-article:18675275 | lifeskim:mentions | umls-concept:C1180347 | lld:lifeskim |
| pubmed-article:18675275 | lifeskim:mentions | umls-concept:C1425496 | lld:lifeskim |
| pubmed-article:18675275 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:18675275 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18675275 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18675275 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18675275 | pubmed:dateCreated | 2008-9-1 | lld:pubmed |
| pubmed-article:18675275 | pubmed:abstractText | The SMARCAD1/KIAA1122 protein is structurally classified into the SWI2/SNF2 superfamily of DNA-dependent ATPases that are catalytic subunits of chromatin-remodeling complexes. Although the importance of other members of the SWR1-like subfamily in chromatin remodeling (EP400, INOC1, and SRCAP) has already been elucidated, the biological function of SMARCAD1/KIAA1122 in transcriptional regulation remains to be clarified. To gain insight into the role of this protein, we generated a specific antibody against SMARCAD1/KIAA1122 and used it for chromatin and protein immunoprecipitation assays. We employed high-resolution genome tiling microarrays in chromatin immunoprecipitation and found the binding sites of SMARCAD1/KIAA1122 in the vicinity of the transcriptional start site of 69 candidate target genes. In the protein immunoprecipitation assay, we found that endogenous SMARCAD1/KIAA1122 binds with TRIM28, a recently highlighted transcriptional regulator in the cancer field. From these findings, we propose a novel model for gene regulation via the SMARCAD1/KIAA1122 protein complex. | lld:pubmed |
| pubmed-article:18675275 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18675275 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18675275 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18675275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18675275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18675275 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18675275 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18675275 | pubmed:issn | 1089-8638 | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:OharaOsamuO | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:NagaseTakahir... | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:OkazakiNoriko... | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:KogaHisashiH | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:OharaReikoR | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:ShimadaKiyoK | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:IkedaShunS | lld:pubmed |
| pubmed-article:18675275 | pubmed:author | pubmed-author:YanagawaToshi... | lld:pubmed |
| pubmed-article:18675275 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18675275 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:18675275 | pubmed:volume | 382 | lld:pubmed |
| pubmed-article:18675275 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18675275 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18675275 | pubmed:pagination | 257-65 | lld:pubmed |
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| pubmed-article:18675275 | pubmed:meshHeading | pubmed-meshheading:18675275... | lld:pubmed |
| pubmed-article:18675275 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18675275 | pubmed:articleTitle | The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS. | lld:pubmed |
| pubmed-article:18675275 | pubmed:affiliation | Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan. | lld:pubmed |
| pubmed-article:18675275 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18675275 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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