| pubmed-article:18665158 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0025011 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0214743 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:18665158 | lifeskim:mentions | umls-concept:C1518581 | lld:lifeskim |
| pubmed-article:18665158 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18665158 | pubmed:dateCreated | 2008-8-26 | lld:pubmed |
| pubmed-article:18665158 | pubmed:abstractText | The majority of glioblastoma multiforme (GBM) tumors (80%) overexpress interleukin-13 receptor alpha2 (IL-13Ralpha2), but there is no expression of IL-13Ralpha2 in normal brain. Vaccine strains of measles virus have significant antitumor activity against gliomas. We tested the hypothesis that measles virus entry could be retargeted via the IL-13Ralpha2. MV-GFP-H(AA)-IL-13 was generated from the Edmonston-NSe vaccine strain, by displaying human IL-13 at the C-terminus of the H protein, and introducing CD46 and signaling lymphocyte activation molecule (SLAM)-ablating mutations in H. The IL-13 retargeted virus showed significant cytopathic effect (CPE) against IL-13Ralpha2 overexpressing glioma lines, and lack of CPE/viral replication in normal human astrocytes and normal human fibroblasts not expressing IL-13Ralpha2. In vivo treatment of orthotopically implanted GBM12 xenografts demonstrated significant prolongation of survival in mice treated with the retargeted strain (P < 0.0001), and comparable activity between the IL-13R retargeted strain and MV-GFP (P = 0.6377). In contrast to MV-GFP-treated mice, administration of the retargeted strain in the central nervous system of measles replication-permissive Ifnar(ko) CD46 Ge mice resulted in lack of neurotoxicity. Strains of measles virus retargeted against the glioma-specific IL-13Ralpha2 receptor have comparable therapeutic efficacy, and improved specificity as compared with the unmodified measles virus strain MV-GFP in vitro and in vivo. | lld:pubmed |
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| pubmed-article:18665158 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18665158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18665158 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18665158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18665158 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18665158 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18665158 | pubmed:issn | 1525-0024 | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:SchroederMark... | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:PuriRaj KRK | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:IankovIankoI | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:RussellStephe... | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:GalanisEvanth... | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:GianniniCater... | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:AllenCoryC | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:SarkariaJannJ | lld:pubmed |
| pubmed-article:18665158 | pubmed:author | pubmed-author:ParaskevakouG... | lld:pubmed |
| pubmed-article:18665158 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18665158 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:18665158 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18665158 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18665158 | pubmed:pagination | 1556-64 | lld:pubmed |
| pubmed-article:18665158 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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