| pubmed-article:18664586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18664586 | lifeskim:mentions | umls-concept:C0023621 | lld:lifeskim |
| pubmed-article:18664586 | pubmed:issue | 31 | lld:pubmed |
| pubmed-article:18664586 | pubmed:dateCreated | 2008-8-6 | lld:pubmed |
| pubmed-article:18664586 | pubmed:abstractText | A unique type of combinatorial protein libraries has been constructed. These libraries are based on the pre-B cell receptor (pre-BCR). The pre-BCR is a protein that is produced during normal development of the antibody repertoire. Unlike that of canonical antibodies, the pre-BCR subunit is a trimer that is composed of an antibody heavy chain paired with two surrogate light chain (SLC) components. Combinatorial libraries based on these pre-BCR proteins in which diverse heavy chains are paired with a fixed SLC were expressed in mammalian, Escherichia coli, and phagemid systems. These libraries contain members that have nanomolar affinity for antigen. We term this type of antigen-binding protein a "surrobody" to distinguish it from the canonical antibody molecule. | lld:pubmed |
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| pubmed-article:18664586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18664586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664586 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18664586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18664586 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18664586 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:LinN CNC | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:LernerRichard... | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:HorowitzMicha... | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:ChanChristina... | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:KashyapArun... | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:YeeHelenaH | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:BhattRamesh... | lld:pubmed |
| pubmed-article:18664586 | pubmed:author | pubmed-author:HorowitzLawre... | lld:pubmed |
| pubmed-article:18664586 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18664586 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:18664586 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:18664586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18664586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18664586 | pubmed:pagination | 10756-61 | lld:pubmed |
| pubmed-article:18664586 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18664586 | pubmed:meshHeading | pubmed-meshheading:18664586... | lld:pubmed |
| pubmed-article:18664586 | pubmed:meshHeading | pubmed-meshheading:18664586... | lld:pubmed |
| pubmed-article:18664586 | pubmed:meshHeading | pubmed-meshheading:18664586... | lld:pubmed |
| pubmed-article:18664586 | pubmed:meshHeading | pubmed-meshheading:18664586... | lld:pubmed |
| pubmed-article:18664586 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18664586 | pubmed:articleTitle | Combinatorial surrobody libraries. | lld:pubmed |
| pubmed-article:18664586 | pubmed:affiliation | Sea Lane Biotechnologies, 1455 Adams Drive, Suite 2060, Menlo Park, CA 94025, USA. | lld:pubmed |
| pubmed-article:18664586 | pubmed:publicationType | Journal Article | lld:pubmed |
