| pubmed-article:18640390 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18640390 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:18640390 | lifeskim:mentions | umls-concept:C0015695 | lld:lifeskim |
| pubmed-article:18640390 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:18640390 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18640390 | pubmed:dateCreated | 2008-7-21 | lld:pubmed |
| pubmed-article:18640390 | pubmed:abstractText | High fructose consumption is associated with the development of fatty liver and dyslipidemia with poorly understood mechanisms. We used a matrix-assisted laser desorption/ionization-based proteomics approach to define the molecular events that link high fructose consumption to fatty liver in hamsters. Hamsters fed high-fructose diet for 8 weeks, as opposed to regular-chow-fed controls, developed hyperinsulinemia and hyperlipidemia. High-fructose-fed hamsters exhibited fat accumulation in liver. Hamsters were killed, and liver tissues were subjected to matrix-assisted laser desorption/ionization-based proteomics. This approach identified a number of proteins whose expression levels were altered by >2-fold in response to high fructose feeding. These proteins fall into 5 different categories including (1) functions in fatty acid metabolism such as fatty acid binding protein and carbamoyl-phosphate synthase; (2) proteins in cholesterol and triglyceride metabolism such as apolipoprotein A-1 and protein disulfide isomerase; (3) molecular chaperones such as GroEL, peroxiredoxin 2, and heat shock protein 70, whose functions are important for protein folding and antioxidation; (4) enzymes in fructose catabolism such as fructose-1,6-bisphosphatase and glycerol kinase; and (5) proteins with housekeeping functions such as albumin. These data provide insight into the molecular basis linking fructose-induced metabolic shift to the development of metabolic syndrome characterized by hepatic steatosis and dyslipidemia. | lld:pubmed |
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| pubmed-article:18640390 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18640390 | pubmed:citationSubset | IM | lld:pubmed |
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