| pubmed-article:18633349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18633349 | lifeskim:mentions | umls-concept:C1853126 | lld:lifeskim |
| pubmed-article:18633349 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:18633349 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:18633349 | lifeskim:mentions | umls-concept:C0182324 | lld:lifeskim |
| pubmed-article:18633349 | pubmed:issue | 7207 | lld:pubmed |
| pubmed-article:18633349 | pubmed:dateCreated | 2008-8-22 | lld:pubmed |
| pubmed-article:18633349 | pubmed:abstractText | Heritable variation is the raw material for evolutionary change, and understanding its genetic basis is one of the central problems in modern biology. We investigated the genetic basis of a classic phenotypic dimorphism in the nematode Caenorhabditis elegans. Males from many natural isolates deposit a copulatory plug after mating, whereas males from other natural isolates?including the standard wild-type strain (N2 Bristol) that is used in most research laboratories?do not deposit plugs. The copulatory plug is a gelatinous mass that covers the hermaphrodite vulva, and its deposition decreases the mating success of subsequent males. We show that the plugging polymorphism results from the insertion of a retrotransposon into an exon of a novel mucin-like gene, plg-1, whose product is a major structural component of the copulatory plug. The gene is expressed in a subset of secretory cells of the male somatic gonad, and its loss has no evident effects beyond the loss of male mate-guarding. Although C. elegans descends from an obligate-outcrossing, male?female ancestor, it occurs primarily as self-fertilizing hermaphrodites. The reduced selection on male?male competition associated with the origin of hermaphroditism may have permitted the global spread of a loss-of-function mutation with restricted pleiotropy. | lld:pubmed |
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| pubmed-article:18633349 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18633349 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18633349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18633349 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18633349 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:KruglyakLeoni... | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:RockmanMatthe... | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:PalopoliMicha... | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:TinMaungAyeA | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:RamsayCamdenC | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:CurwenStephen... | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:AdunaAndreaA | lld:pubmed |
| pubmed-article:18633349 | pubmed:author | pubmed-author:LauritaJasonJ | lld:pubmed |
| pubmed-article:18633349 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18633349 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:18633349 | pubmed:volume | 454 | lld:pubmed |
| pubmed-article:18633349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18633349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18633349 | pubmed:pagination | 1019-22 | lld:pubmed |
| pubmed-article:18633349 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:18633349 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18633349 | pubmed:articleTitle | Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:18633349 | pubmed:affiliation | Department of Biology, Bowdoin College, 6500 College Station, Brunswick, Maine 04011, USA. mpalopol@bowdoin.edu | lld:pubmed |
| pubmed-article:18633349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18633349 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18633349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18633349 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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