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pubmed-article:18618617pubmed:abstractTextSystemic and inhalation therapy of granulocyte-macrophage colony-stimulating factor (GM-CSF) is usually effective in controlling autoimmune pulmonary alveolar proteinosis (PAP), but some cases are refractory to GM-CSF therapy and subjected to whole lung lavage (WLL). A 9-year-old girl developed severe respiratory failure due to autoimmune PAP was treated with inhalational 250 microg of GM-CSF daily, however, it was ineffective. Unilateral WLL was performed three times and subsequent GM-CSF inhalation therapy yielded marked physiological and radiological improvement and was continued for 1 year.lld:pubmed
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pubmed-article:18618617pubmed:copyrightInfo(c) 2008 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:18618617pubmed:volume43lld:pubmed
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pubmed-article:18618617pubmed:year2008lld:pubmed
pubmed-article:18618617pubmed:articleTitleA combination therapy of whole lung lavage and GM-CSF inhalation in pulmonary alveolar proteinosis.lld:pubmed
pubmed-article:18618617pubmed:affiliationDepartment of Pediatrics, Aichi Medical University School of Medicine, Aichi, Japan.lld:pubmed
pubmed-article:18618617pubmed:publicationTypeJournal Articlelld:pubmed
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