| pubmed-article:18591409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18591409 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:18591409 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:18591409 | lifeskim:mentions | umls-concept:C1537399 | lld:lifeskim |
| pubmed-article:18591409 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18591409 | pubmed:dateCreated | 2008-7-11 | lld:pubmed |
| pubmed-article:18591409 | pubmed:abstractText | The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) recognize distinct viral and synthetic RNAs, leading to the production of interferons. Although 5'-triphosphate single-stranded RNA is a RIG-I ligand, the role of RIG-I and MDA5 in double-stranded (ds) RNA recognition remains to be characterized. In this study, we show that the length of dsRNA is important for differential recognition by RIG-I and MDA5. The MDA5 ligand, polyinosinic-polycytidylic acid, was converted to a RIG-I ligand after shortening of the dsRNA length. In addition, viral dsRNAs differentially activated RIG-I and MDA5, depending on their length. Vesicular stomatitis virus infection generated dsRNA, which is responsible for RIG-I-mediated recognition. Collectively, RIG-I detects dsRNAs without a 5'-triphosphate end, and RIG-I and MDA5 selectively recognize short and long dsRNAs, respectively. | lld:pubmed |
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| pubmed-article:18591409 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18591409 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18591409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18591409 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18591409 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:AkiraShizuoS | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:DermodyTerenc... | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:FujitaTakashi... | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:KawaiTomojiT | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:TakeuchiOsamu... | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:KatoHirokiH | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:HiraiReikoR | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:MatsushitaKaz... | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:Mikamo-SatohE... | lld:pubmed |
| pubmed-article:18591409 | pubmed:author | pubmed-author:HiiragiAkaneA | lld:pubmed |
| pubmed-article:18591409 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18591409 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:18591409 | pubmed:volume | 205 | lld:pubmed |
| pubmed-article:18591409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18591409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18591409 | pubmed:pagination | 1601-10 | lld:pubmed |
| pubmed-article:18591409 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18591409 | pubmed:meshHeading | pubmed-meshheading:18591409... | lld:pubmed |
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| pubmed-article:18591409 | pubmed:meshHeading | pubmed-meshheading:18591409... | lld:pubmed |
| pubmed-article:18591409 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18591409 | pubmed:articleTitle | Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. | lld:pubmed |
| pubmed-article:18591409 | pubmed:affiliation | Laboratory of Host Defense, World Premiere International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:18591409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18591409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18591409 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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