| pubmed-article:18579694 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
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| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C0439834 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C0456962 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C0067533 | lld:lifeskim |
| pubmed-article:18579694 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18579694 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18579694 | pubmed:dateCreated | 2008-8-4 | lld:pubmed |
| pubmed-article:18579694 | pubmed:abstractText | This study investigated interleukin-4 (IL-4), IL-4 delta 2, transforming growth factor beta (TGF-beta), TGF-beta RII, Foxp3, GATA-3, T-bet, and gamma interferon (IFN-gamma) transcription in peripheral blood samples of adult pulmonary tuberculosis patients prior to and after 1 week of therapy. Twenty patients with positive results for sputum culture for Mycobacterium tuberculosis were enrolled and treated with directly observed short-course antituberculosis chemotherapy. Early treatment response was assessed. At the end of the intensive phase of treatment (month 2), 12 patients remained sputum culture positive (slow responders) and 8 converted to a negative culture (fast responders). Only the expression levels of IL-4 (4-fold decrease) and IL-4 delta 2 (32-fold increase) changed significantly during the first week of therapy in the 20 patients. No baseline differences were present between the responder groups, but fast responders had significantly higher IL-4 transcripts than slow responders at week 1. Fast responders showed a 19-fold upregulation and slow responders a 47-fold upregulation of IL-4 delta 2 at week 1. Only slow responders also showed a significant decrease in IL-4 expression at week 1. There were no significant differences in expression of TGF-beta, TGF-beta RII, Foxp3, IFN-gamma, and GATA-3 between the groups. These data show that differential IL-4-related gene expression in the early stage of antituberculosis treatment accompanies differential treatment responses and may hold promise as a marker for treatment effect. | lld:pubmed |
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| pubmed-article:18579694 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18579694 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18579694 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18579694 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18579694 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18579694 | pubmed:issn | 1556-679X | lld:pubmed |
| pubmed-article:18579694 | pubmed:author | pubmed-author:BeyersNuldaN | lld:pubmed |
| pubmed-article:18579694 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:18579694 | pubmed:author | pubmed-author:WalzlGerhardG | lld:pubmed |
| pubmed-article:18579694 | pubmed:author | pubmed-author:RonacherKatha... | lld:pubmed |
| pubmed-article:18579694 | pubmed:author | pubmed-author:Djoba... | lld:pubmed |
| pubmed-article:18579694 | pubmed:author | pubmed-author:BapelaNchinya... | lld:pubmed |
| pubmed-article:18579694 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18579694 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:18579694 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18579694 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18579694 | pubmed:pagination | 1165-70 | lld:pubmed |
| pubmed-article:18579694 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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