| pubmed-article:18568034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18568034 | lifeskim:mentions | umls-concept:C0032143 | lld:lifeskim |
| pubmed-article:18568034 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:18568034 | lifeskim:mentions | umls-concept:C0948008 | lld:lifeskim |
| pubmed-article:18568034 | lifeskim:mentions | umls-concept:C0916084 | lld:lifeskim |
| pubmed-article:18568034 | lifeskim:mentions | umls-concept:C1947912 | lld:lifeskim |
| pubmed-article:18568034 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18568034 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18568034 | pubmed:dateCreated | 2008-7-8 | lld:pubmed |
| pubmed-article:18568034 | pubmed:abstractText | Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is markedly limited owing to concerns about hemorrhagic complications and the requirement that tPA be administered within 3 h of symptoms. Here we report that tPA activation of latent platelet-derived growth factor-CC (PDGF-CC) may explain these limitations. Intraventricular injection of tPA or active PDGF-CC, in the absence of ischemia, leads to significant increases in cerebrovascular permeability. In contrast, co-injection of neutralizing antibodies to PDGF-CC with tPA blocks this increased permeability, indicating that PDGF-CC is a downstream substrate of tPA within the neurovascular unit. These effects are mediated through activation of PDGF-alpha receptors (PDGFR-alpha) on perivascular astrocytes, and treatment of mice with the PDGFR-alpha antagonist imatinib after ischemic stroke reduces both cerebrovascular permeability and hemorrhagic complications associated with late administration of thrombolytic tPA. These data demonstrate that PDGF signaling regulates blood-brain barrier permeability and suggest potential new strategies for stroke treatment. | lld:pubmed |
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| pubmed-article:18568034 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18568034 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18568034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18568034 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18568034 | pubmed:issn | 1546-170X | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:BetsholtzChri... | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:ErikssonUlfU | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:StricklandDud... | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:LawrenceDanie... | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:PietrasKristi... | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:YepesManuelM | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:AndraeJohanna... | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:FredrikssonLi... | lld:pubmed |
| pubmed-article:18568034 | pubmed:author | pubmed-author:GaoYameiY | lld:pubmed |
