| pubmed-article:18534992 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C0028246 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18534992 | lifeskim:mentions | umls-concept:C0205146 | lld:lifeskim |
| pubmed-article:18534992 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18534992 | pubmed:dateCreated | 2009-1-12 | lld:pubmed |
| pubmed-article:18534992 | pubmed:abstractText | Area 3a neurons are identified that respond weakly or not at all to skin contact with a 25-38 degrees C probe, but vigorously to skin contact with the probe at > or =49 degrees C. Maximal rate of spike firing associated with 1- to 7-s contact at > or =49 degrees C occurs 1-2 s after probe removal from the skin. The activity evoked by 5-s contact with the probe at 51 degrees C remains above-background for approximately 20 s after probe retraction. After 1-s contact at 55-56 degrees C activity remains above-background for approximately 4 s. Magnitude of spike firing associated with 5-s contact increases linearly as probe temperature is increased from 49-51 degrees C. Intradermal capsaicin injection elicits a larger (approximately 2.5x) and longer-lasting (100x) increase in area 3a neuron firing rate than 5-s contact at 51 degrees C. Area 3a neurons exhibit enhanced or novel responsivity to 25-38 degrees C contact for a prolonged time after intradermal injection of capsaicin or alpha, beta methylene adenosine triphosphate. Their 1) delayed and persisting increase in spike firing in response to contact at > or =49 degrees C, 2) vigorous and prolonged response to intradermal capsaicin, and 3) enhanced and frequently novel response to 25-38 degrees C contact following intradermal algogen injection or noxious skin heating suggest that the area 3a neurons identified in this study contribute to second pain and mechanical hyperalgesia/allodynia. | lld:pubmed |
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| pubmed-article:18534992 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18534992 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18534992 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18534992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18534992 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18534992 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18534992 | pubmed:issn | 1460-2199 | lld:pubmed |
| pubmed-article:18534992 | pubmed:author | pubmed-author:TommerdahlMar... | lld:pubmed |
| pubmed-article:18534992 | pubmed:author | pubmed-author:WhitselBarry... | lld:pubmed |
| pubmed-article:18534992 | pubmed:author | pubmed-author:LiYongbiaoY | lld:pubmed |
| pubmed-article:18534992 | pubmed:author | pubmed-author:FavorovOleg... | lld:pubmed |
| pubmed-article:18534992 | pubmed:author | pubmed-author:QuibreraMigue... | lld:pubmed |
| pubmed-article:18534992 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18534992 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18534992 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18534992 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18534992 | pubmed:pagination | 349-66 | lld:pubmed |
| pubmed-article:18534992 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
| pubmed-article:18534992 | pubmed:meshHeading | pubmed-meshheading:18534992... | lld:pubmed |
