| pubmed-article:18506399 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18506399 | lifeskim:mentions | umls-concept:C0332441 | lld:lifeskim |
| pubmed-article:18506399 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:18506399 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:18506399 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18506399 | pubmed:dateCreated | 2008-7-25 | lld:pubmed |
| pubmed-article:18506399 | pubmed:abstractText | Over the past five decades, those interested in markers of radiation effect have focused primarily on tumor response. More recently, however, the view has broadened to include irradiated normal tissues-markers that predict unusual risk of side-effects, prognosticate during the prodromal and therapeutic phases, diagnose a particular toxicity as radiation-related, and, in the case of bioterror, allow for tissue-specific biodosimetry. Currently, there are few clinically useful radiation-related biomarkers. Notably, levels of some hormones such as thyroid-stimulating hormone (TSH) have been used successfully as markers of dysfunction, indicative of the need for replacement therapy, and for prevention of cancers. The most promising macromolecular markers are cytokines: TGFbeta, IL-1, IL-6, and TNFalpha being lead molecules in this class as both markers and targets for therapy. Genomics and proteomics are still in nascent stages and are actively being studied and developed. | lld:pubmed |
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| pubmed-article:18506399 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18506399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18506399 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18506399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18506399 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18506399 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18506399 | pubmed:issn | 0167-7659 | lld:pubmed |
| pubmed-article:18506399 | pubmed:author | pubmed-author:OkunieffPaulP | lld:pubmed |
| pubmed-article:18506399 | pubmed:author | pubmed-author:ChenYuhchyauY | lld:pubmed |
| pubmed-article:18506399 | pubmed:author | pubmed-author:MaguireDavid... | lld:pubmed |
| pubmed-article:18506399 | pubmed:author | pubmed-author:HuserAmy KAK | lld:pubmed |
| pubmed-article:18506399 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18506399 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:18506399 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18506399 | pubmed:authorsComplete | Y | lld:pubmed |
