| pubmed-article:1850029 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1850029 | lifeskim:mentions | umls-concept:C0035869 | lld:lifeskim |
| pubmed-article:1850029 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1850029 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:1850029 | lifeskim:mentions | umls-concept:C0282557 | lld:lifeskim |
| pubmed-article:1850029 | lifeskim:mentions | umls-concept:C0205473 | lld:lifeskim |
| pubmed-article:1850029 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1850029 | pubmed:dateCreated | 1991-5-20 | lld:pubmed |
| pubmed-article:1850029 | pubmed:abstractText | We examined the humoral immune response to rotavirus infection in specific pathogen-free rabbits inoculated and challenged orally with rabbit Ala rotavirus (7.5 x 10(5) to 1 x 10(7) PFU). The humoral immune response in both serologic and mucosal samples was monitored by using total antibody enzyme-linked immunosorbent assays (ELISAs), isotype-specific ELISAs, and plaque reduction neutralization assays. Following a primary infection, all rabbits shed virus and serologic and mucosal antibody responses were initially detected by 1 week postinoculation. Intestinal immunoglobulin M was detected by 3 days postinoculation, and secretory immunoglobulin A was detected by 6 days postinoculation. Following challenge, rabbits were protected (no detectable virus shedding) from infection. An anamnestic immune response was observed only with mucosal neutralizing antibodies, and all serologic and mucosal immune responses persisted at high levels until at least 175 days postchallenge (204 days postinoculation). Detection of neutralization responses was influenced by the virus strain used in the neutralization assay; all inoculated rabbits developed detectable serum and intestinal neutralizing antibodies against the infecting (Ala) virus strain. Neutralization activity in both serum and mucosal samples was generally, but not exclusively, homotypic (VP7 serotype 3) after both primary and challenge inoculations with Ala virus. Heterotypic serum neutralization activity was observed with serotype 8 (9 of 12 rabbits) and 9 (12 of 12 rabbits) viruses and may be based on reactivity with the outer capsid protein VP4 or on a shared epitope in the C region of VP7. Comparisons of heterologous (serotype 3) and heterotypic neutralizing responses in mucosal and serologic samples revealed that 43% (21 of 49) of the responses were discordant. In 19 of 49 (39%) of these cases, a heterotypic serologic response was seen in the absence of a heterotypic mucosal response, but in 2 of 49 (4%) instances, a heterotypic mucosal response was seen in the absence of a concomitant serologic response. These results provide insight into factors which may affect detection of heterotypic responses. | lld:pubmed |
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| pubmed-article:1850029 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1850029 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1850029 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1850029 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1850029 | pubmed:month | May | lld:pubmed |
| pubmed-article:1850029 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1850029 | pubmed:author | pubmed-author:GrahamD YDY | lld:pubmed |
| pubmed-article:1850029 | pubmed:author | pubmed-author:EstesM KMK | lld:pubmed |
| pubmed-article:1850029 | pubmed:author | pubmed-author:ConnerM EME | lld:pubmed |
| pubmed-article:1850029 | pubmed:author | pubmed-author:GilgerM AMA | lld:pubmed |
| pubmed-article:1850029 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1850029 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:1850029 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1850029 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1850029 | pubmed:pagination | 2562-71 | lld:pubmed |
| pubmed-article:1850029 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:1850029 | pubmed:meshHeading | pubmed-meshheading:1850029-... | lld:pubmed |
| pubmed-article:1850029 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1850029 | pubmed:articleTitle | Serologic and mucosal immune response to rotavirus infection in the rabbit model. | lld:pubmed |
