| pubmed-article:1847170 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0003695 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0013725 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0243127 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0596233 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1847170 | lifeskim:mentions | umls-concept:C0443331 | lld:lifeskim |
| pubmed-article:1847170 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1847170 | pubmed:dateCreated | 1991-3-19 | lld:pubmed |
| pubmed-article:1847170 | pubmed:abstractText | Platelet-activating factor is a potent mediator of the inflammatory response. Studies of the actions of platelet-activating factor have centered mainly around neutrophils, monocytes, and platelets. In this report we begin to uncover the influence of platelet-activating factor on B lymphocytes. Employing the EBV-transformed human B cell line SKW6.4, we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine, phosphatidylinositol, and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M. The inactive precursor, lyso-platelet-activating factor, at a concentration as high as 10(-7) M had no effect on any of the membrane phospholipids. We also show that platelet-activating factor from 10(-12) to 10(-6) M induced rapid and significant elevation in intracellular calcium levels, whereas lyso-platelet-activating factor was again ineffective. We further demonstrate the impact of platelet-activating factor binding to B cells by measuring platelet-activating factor induced arachidonic acid release and 5-hydroxyeicosatetraenoic acid production. Moreover, platelet-activating factor was capable of inducing transcription of the nuclear proto-oncogenes c-fos and c-jun. Finally we explored the possible role of 5-hydroxyeicosatetraenoic acid as a regulator of arachidonic acid liberation demonstrating that endogenous 5-lipoxygenase activity modulates platelet-activating factor induced arachidonic acid release perhaps acting at the level of phospholipase A2. In summary, platelet-activating factor is shown here to have a direct and profound effect on a pure B cell line. | lld:pubmed |
| pubmed-article:1847170 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1847170 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1847170 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1847170 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1847170 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1847170 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1847170 | pubmed:author | pubmed-author:ShearerW TWT | lld:pubmed |
| pubmed-article:1847170 | pubmed:author | pubmed-author:KuruvillaAA | lld:pubmed |
| pubmed-article:1847170 | pubmed:author | pubmed-author:PutchaGG | lld:pubmed |
| pubmed-article:1847170 | pubmed:author | pubmed-author:SchulamP GPG | lld:pubmed |
| pubmed-article:1847170 | pubmed:author | pubmed-author:Franklin-John... | lld:pubmed |
| pubmed-article:1847170 | pubmed:author | pubmed-author:MangusLL | lld:pubmed |
| pubmed-article:1847170 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1847170 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1847170 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1847170 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:1847170 | pubmed:geneSymbol | c-jun | lld:pubmed |
| pubmed-article:1847170 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1847170 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1847170 | pubmed:pagination | 1642-8 | lld:pubmed |
| pubmed-article:1847170 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1847170 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1847170 | pubmed:articleTitle | Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line. | lld:pubmed |
| pubmed-article:1847170 | pubmed:affiliation | Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030. | lld:pubmed |
| pubmed-article:1847170 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1847170 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1847170 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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