| pubmed-article:18440099 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C2825575 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C0332516 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18440099 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:18440099 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18440099 | pubmed:dateCreated | 2008-12-31 | lld:pubmed |
| pubmed-article:18440099 | pubmed:abstractText | A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI(50)=0.04 microM) and HL-60 (GI(50)=0.09 microM) cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration. | lld:pubmed |
| pubmed-article:18440099 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18440099 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18440099 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18440099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18440099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18440099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18440099 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18440099 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18440099 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:LinShinne-Ren... | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:ChangLong-Sen... | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:WuMing-JungMJ | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:LinChi-FongCF | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:HuYi-LingYL | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:LoYu-HsiangYH | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:YangSheng-Hue... | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:TsengKuo-Feng... | lld:pubmed |
| pubmed-article:18440099 | pubmed:author | pubmed-author:ChenLi-YiLY | lld:pubmed |
| pubmed-article:18440099 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18440099 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:18440099 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18440099 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18440099 | pubmed:pagination | 35-41 | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:meshHeading | pubmed-meshheading:18440099... | lld:pubmed |
| pubmed-article:18440099 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18440099 | pubmed:articleTitle | Synthesis and biological evaluation of novel symmetry bis-enediynes. | lld:pubmed |
| pubmed-article:18440099 | pubmed:affiliation | Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan. | lld:pubmed |
| pubmed-article:18440099 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18440099 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18440099 | lld:chembl |
