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pubmed-article:18438878pubmed:abstractTextErlotinib is an orally available, reversible inhibitor of epidermal growth factor receptor (EGFR) with a proven survival advantage for patients with locally advanced or metastatic nonsmall cell lung cancer (NSCLC) who have failed a prior chemotherapy. This phase 3b, multicenter, open-label trial of erlotinib in patients with advanced NSCLC who had progressed after standard chemotherapy treatment was conducted to examine the efficacy and safety of erlotinib monotherapy in patients with advanced NSCLC who had developed disease progression after previous chemotherapy and to characterize the duration of survival and the response rate of erlotinib-treated patients in subpopulations defined by other patient characteristics before U.S. Food and Drug Administration approval.lld:pubmed
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pubmed-article:18438878pubmed:copyrightInfoCopyright (c) 2008 American Cancer Society.lld:pubmed
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pubmed-article:18438878pubmed:articleTitleFinal survival and safety results from a multicenter, open-label, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer.lld:pubmed
pubmed-article:18438878pubmed:affiliationSarah Cannon Research Institute, Nashville, Tennessee 37203, USA. dspigel@tnonc.comlld:pubmed
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