| pubmed-article:18414472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18414472 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:18414472 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:18414472 | lifeskim:mentions | umls-concept:C1414532 | lld:lifeskim |
| pubmed-article:18414472 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:18414472 | lifeskim:mentions | umls-concept:C1512554 | lld:lifeskim |
| pubmed-article:18414472 | lifeskim:mentions | umls-concept:C0205179 | lld:lifeskim |
| pubmed-article:18414472 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18414472 | pubmed:dateCreated | 2008-4-16 | lld:pubmed |
| pubmed-article:18414472 | pubmed:abstractText | The Fanconi gene family has a role in DNA repair and inactivation of FANCF has been proposed as a mechanism of sensitisation to platinum chemotherapy. This study sought to confirm this hypothesis in cell lines and a large series of ovarian cancer samples. Promoter methylation was assessed by methylation-sensitive polymerase chain reaction of FANCF in nine ovarian cancer cell lines and 74 ovarian cancer samples taken from patients entered on a trial of cisplatin-based chemotherapy. This study confirmed methylation-dependent silencing of FANCF in one out of nine ovarian cancer cell lines. Methylation of FANCF was demonstrated in 13.2% of 53 evaluable ovarian tumour samples. Progression-free survival gave an HR of 3.63 (95% CI: 1.54-8.54, P=0.0016) in favour of the unmethylated cases. There was no association with overall survival. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer. | lld:pubmed |
| pubmed-article:18414472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18414472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18414472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18414472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18414472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18414472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18414472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18414472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18414472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18414472 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18414472 | pubmed:issn | 1532-1827 | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:SmithPP | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:GreenJ AJA | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:CoeneMM | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:HEYE NEN | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:WongHH | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:CrookTT | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:SyedNN | lld:pubmed |
| pubmed-article:18414472 | pubmed:author | pubmed-author:SzlosarekPP | lld:pubmed |
| pubmed-article:18414472 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18414472 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:18414472 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:18414472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18414472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18414472 | pubmed:pagination | 1452-6 | lld:pubmed |
| pubmed-article:18414472 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:meshHeading | pubmed-meshheading:18414472... | lld:pubmed |
| pubmed-article:18414472 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18414472 | pubmed:articleTitle | Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer. | lld:pubmed |
| pubmed-article:18414472 | pubmed:affiliation | Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK. | lld:pubmed |
| pubmed-article:18414472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18414472 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| lhgdn:association:44743 | lhgdn:found_in | pubmed-article:18414472 | lld:lhgdn |
