| pubmed-article:18393307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18393307 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:18393307 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18393307 | lifeskim:mentions | umls-concept:C0700374 | lld:lifeskim |
| pubmed-article:18393307 | lifeskim:mentions | umls-concept:C0205094 | lld:lifeskim |
| pubmed-article:18393307 | lifeskim:mentions | umls-concept:C0205242 | lld:lifeskim |
| pubmed-article:18393307 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18393307 | pubmed:dateCreated | 2008-4-30 | lld:pubmed |
| pubmed-article:18393307 | pubmed:abstractText | Many genes are known to function in a region-specific manner in the developing secondary palate. We have previously shown that Shox2-deficient embryos die at mid-gestation stage and develop an anterior clefting phenotype. Here, we show that mice carrying a conditional inactivation of Shox2 in the palatal mesenchyme survive the embryonic and neonatal lethality, but develop a wasting syndrome. Phenotypic analyses indicate a delayed closure of the secondary palate at the anterior end, leading to a failed fusion of the primary and secondary palates. Consistent with a role proposed for Shox2 in skeletogenesis, Shox2 inactivation causes a significantly reduced bone formation in the hard palate, probably due to a down-regulation of Runx2 and Osterix. We conclude that the secondary palatal shelves are capable of fusion with each other, but fail to fuse with the primary palate in a developmentally delayed manner. Mice carrying an anterior cleft can survive neonatal lethality. | lld:pubmed |
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| pubmed-article:18393307 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18393307 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18393307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18393307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18393307 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18393307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18393307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18393307 | pubmed:month | May | lld:pubmed |
| pubmed-article:18393307 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:18393307 | pubmed:author | pubmed-author:YehTT | lld:pubmed |
| pubmed-article:18393307 | pubmed:author | pubmed-author:YuXueyanX | lld:pubmed |
| pubmed-article:18393307 | pubmed:author | pubmed-author:ChenYiPingY | lld:pubmed |
| pubmed-article:18393307 | pubmed:author | pubmed-author:FeiJianJ | lld:pubmed |
| pubmed-article:18393307 | pubmed:author | pubmed-author:JiangYipingY | lld:pubmed |
| pubmed-article:18393307 | pubmed:author | pubmed-author:GuShupingS | lld:pubmed |
| pubmed-article:18393307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18393307 | pubmed:volume | 237 | lld:pubmed |
| pubmed-article:18393307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18393307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18393307 | pubmed:pagination | 1509-16 | lld:pubmed |
| pubmed-article:18393307 | pubmed:dateRevised | 2011-6-8 | lld:pubmed |
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| pubmed-article:18393307 | pubmed:meshHeading | pubmed-meshheading:18393307... | lld:pubmed |
| pubmed-article:18393307 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18393307 | pubmed:articleTitle | Mice with an anterior cleft of the palate survive neonatal lethality. | lld:pubmed |
| pubmed-article:18393307 | pubmed:affiliation | Section of Oral Biology, The Ohio State University College of Dentistry, Columbus, Ohio 43210, USA. | lld:pubmed |
| pubmed-article:18393307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18393307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18393307 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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