Linked Life Data

18381411

Source:http://linkedlifedata.com/resource/pubmed/id/18381411

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pubmed-article:18381411pubmed:abstractTextBreast cancer outcome is highly variable. Whether inadvertent exposure to environmental xenobiotics evokes a biological response promoting cancer aggressiveness and a higher probability of tumor recurrence remains unknown. To determine specific molecular alterations which arise in high-risk breast tissue in the presence of the ubiquitous xenoestrogen, bisphenol A (BPA), we used nonmalignant random periareolar fine-needle aspirates in a novel functional assay. Early events induced by BPA in epithelial-stromal cocultures derived from the contralateral tissue of patients with breast cancer included gene expression patterns which facilitate apoptosis evasion, endurance of microenvironmental stress, and cell cycle deregulation without a detectable increase in cell numbers. This BPA response profile was significantly associated with breast tumors characterized by high histologic grade (P < 0.001) and large tumor size (P = 0.002), resulting in decreased recurrence-free patient survival (P < 0.001). Our assays show a biological "fingerprint" of probable prior exposure to endocrine-disrupting agents, and suggest a scenario in which their presence in the microenvironmental milieu of high-risk breast tissue could play a deterministic role in establishing and maintaining tumor aggressiveness and poor patient outcome.lld:pubmed
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pubmed-article:18381411pubmed:articleTitleBisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients.lld:pubmed
pubmed-article:18381411pubmed:affiliationCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA. dairkes@cpmcri.orglld:pubmed
pubmed-article:18381411pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18381411pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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