| pubmed-article:18371448 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18371448 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18371448 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18371448 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:18371448 | lifeskim:mentions | umls-concept:C2717959 | lld:lifeskim |
| pubmed-article:18371448 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:18371448 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18371448 | pubmed:dateCreated | 2008-3-28 | lld:pubmed |
| pubmed-article:18371448 | pubmed:abstractText | Ectopic expression of the transcription factors Oct4, Sox2, c-Myc, and Klf4 in fibroblasts generates induced pluripotent stem (iPS) cells. Little is known about the nature and sequence of molecular events accompanying nuclear reprogramming. Using doxycycline-inducible vectors, we have shown that exogenous factors are required for about 10 days, after which cells enter a self-sustaining pluripotent state. We have identified markers that define cell populations prior to and during this transition period. While downregulation of Thy1 and subsequent upregulation of SSEA-1 occur at early time points, reactivation of endogenous Oct4, Sox2, telomerase, and the silent X chromosome mark late events in the reprogramming process. Cell sorting with these markers allows for a significant enrichment of cells with the potential to become iPS cells. Our results suggest that factor-induced reprogramming is a gradual process with defined intermediate cell populations that contain the majority of cells poised to become iPS cells. | lld:pubmed |
| pubmed-article:18371448 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18371448 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18371448 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18371448 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18371448 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18371448 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18371448 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18371448 | pubmed:issn | 1875-9777 | lld:pubmed |
| pubmed-article:18371448 | pubmed:author | pubmed-author:HochedlingerK... | lld:pubmed |
| pubmed-article:18371448 | pubmed:author | pubmed-author:StadtfeldMatt... | lld:pubmed |
| pubmed-article:18371448 | pubmed:author | pubmed-author:BreaultDavid... | lld:pubmed |
| pubmed-article:18371448 | pubmed:author | pubmed-author:MaheraliNimet... | lld:pubmed |
| pubmed-article:18371448 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18371448 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:18371448 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:18371448 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18371448 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18371448 | pubmed:pagination | 230-40 | lld:pubmed |
| pubmed-article:18371448 | pubmed:dateRevised | 2011-6-14 | lld:pubmed |
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| pubmed-article:18371448 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18371448 | pubmed:articleTitle | Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. | lld:pubmed |
| pubmed-article:18371448 | pubmed:affiliation | Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA. | lld:pubmed |
| pubmed-article:18371448 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18371448 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18371448 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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