| pubmed-article:18342604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C1522290 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C1420412 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:18342604 | lifeskim:mentions | umls-concept:C0332246 | lld:lifeskim |
| pubmed-article:18342604 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18342604 | pubmed:dateCreated | 2008-3-17 | lld:pubmed |
| pubmed-article:18342604 | pubmed:abstractText | The 2.9 A crystal structure of the core SRPK1:ASF/SF2 complex reveals that the N-terminal half of the basic RS domain of ASF/SF2, which is destined to be phosphorylated, is bound to an acidic docking groove of SRPK1 distal to the active site. Phosphorylation of ASF/SF2 at a single site in the C-terminal end of the RS domain generates a primed phosphoserine that binds to a basic site in the kinase. Biochemical experiments support a directional sliding of the RS peptide through the docking groove to the active site during phosphorylation, which ends with the unfolding of a beta strand of the RRM domain and binding of the unfolded region to the docking groove. We further suggest that the priming of the first serine facilitates directional substrate translocation and efficient phosphorylation. | lld:pubmed |
| pubmed-article:18342604 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18342604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18342604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18342604 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18342604 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:FuXiang-DongX... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:GhoshGourisan... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:DorresteinPie... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:HagopianJonat... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:AdamsJoseph... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:ChakrabartiSu... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:MaChen-TingCT | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:NgoJacky... | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:GiangKaylaK | lld:pubmed |
| pubmed-article:18342604 | pubmed:author | pubmed-author:HuynhNhatN | lld:pubmed |
| pubmed-article:18342604 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18342604 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:18342604 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:18342604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18342604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18342604 | pubmed:pagination | 563-76 | lld:pubmed |
| pubmed-article:18342604 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:18342604 | pubmed:meshHeading | pubmed-meshheading:18342604... | lld:pubmed |
| pubmed-article:18342604 | pubmed:meshHeading | pubmed-meshheading:18342604... | lld:pubmed |
