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pubmed-article:18334033pubmed:abstractTextCognate immunity against neoplastic cells depends on a balance between effector T cells and regulatory T (Treg) cells. Treg cells prevent immune attack against normal and neoplastic cells by directly suppressing the activation of effector CD4+ and CD8+ T cells. We postulated that a recombinant interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; Ontak) may serve as a useful strategy to deplete Treg cells and break tolerance against neoplastic tumors in humans.lld:pubmed
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pubmed-article:18334033pubmed:articleTitleTransient T cell depletion causes regression of melanoma metastases.lld:pubmed
pubmed-article:18334033pubmed:affiliationMolecular Targets Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA. m0rask01@gwise.louisville.edulld:pubmed
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