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pubmed-article:18327586pubmed:abstractTextEpidermal growth factor receptor-overexpression reported in colorectal cancer, justifies therapeutic use of EGFR-inhibitors. We have recently conducted a phase II study in 57 patients with EGFR-positive advanced colorectal cancer (ACC) who received gefitinib-FOLFOX6 followed by gefitinib-single agent as maintenance. Main biological objective was to assess sEGFR as surrogate marker of tyrosine kinase inhibition and as predictor of response.lld:pubmed
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pubmed-article:18327586pubmed:articleTitleEpidermal growth factor receptor serum (sEGFR) level may predict response in patients with EGFR-positive advanced colorectal cancer treated with gefitinib?lld:pubmed
pubmed-article:18327586pubmed:affiliationDepartment of Medicine, Medical Care Unit, European Institute of Oncology, Milan, Italy. maria.zampino@ieo.itlld:pubmed
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