| pubmed-article:1832279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1832279 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:1832279 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:1832279 | lifeskim:mentions | umls-concept:C0001451 | lld:lifeskim |
| pubmed-article:1832279 | lifeskim:mentions | umls-concept:C0018549 | lld:lifeskim |
| pubmed-article:1832279 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:1832279 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:1832279 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1832279 | pubmed:dateCreated | 1991-10-4 | lld:pubmed |
| pubmed-article:1832279 | pubmed:abstractText | The influence of halothane on the interactions of 5-HT1A and adenosine A1 receptors with G proteins was determined by monitoring the guanine nucleotide sensitivity of agonist binding to these receptors. Halothane inhibited the binding of radiolabeled agonists to 5-HT1A and adenosine A1 receptors by up to 30%, but only at concentrations considerably greater than those necessary for the maintenance of the anesthetic state. The sensitivity of high-affinity agonist binding to a guanine nucleotide (guanylyl-5'-imidodiphosphate) was not affected by halothane, indicating no disruption of receptor-G protein coupling. Thus, it appears that the ability of halothane to disrupt receptor-mediated signal transduction by interference with receptor-G protein interactions is receptor specific. | lld:pubmed |
| pubmed-article:1832279 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1832279 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1832279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1832279 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1832279 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:1832279 | pubmed:author | pubmed-author:AronstamR SRS | lld:pubmed |
| pubmed-article:1832279 | pubmed:author | pubmed-author:MartinD CDC | lld:pubmed |
| pubmed-article:1832279 | pubmed:author | pubmed-author:IntronaR PRP | lld:pubmed |
| pubmed-article:1832279 | pubmed:author | pubmed-author:DennisonR LRL | lld:pubmed |
| pubmed-article:1832279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1832279 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:1832279 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:1832279 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1832279 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1832279 | pubmed:pagination | 1313-6 | lld:pubmed |
| pubmed-article:1832279 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
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| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:meshHeading | pubmed-meshheading:1832279-... | lld:pubmed |
| pubmed-article:1832279 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1832279 | pubmed:articleTitle | Influence of halothane on the interactions of serotonin1A and adenosine A1 receptors with G proteins in rat brain membranes. | lld:pubmed |
| pubmed-article:1832279 | pubmed:affiliation | Department of Anesthesiology, Medical College of Georgia, Augusta 30912-2700. | lld:pubmed |
| pubmed-article:1832279 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1832279 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1832279 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
