| pubmed-article:18316525 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18316525 | lifeskim:mentions | umls-concept:C0019994 | lld:lifeskim |
| pubmed-article:18316525 | lifeskim:mentions | umls-concept:C0009462 | lld:lifeskim |
| pubmed-article:18316525 | lifeskim:mentions | umls-concept:C0887953 | lld:lifeskim |
| pubmed-article:18316525 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18316525 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:18316525 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:18316525 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18316525 | pubmed:dateCreated | 2008-4-25 | lld:pubmed |
| pubmed-article:18316525 | pubmed:abstractText | Rx-01_423 and Rx-01_667 are two members of the family of oxazolidinones that were designed using a combination of computational and medicinal chemistry and conventional biological techniques. The compounds have a two- to eightfold-improved potency over linezolid against serious gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant streptococci, and vancomycin-resistant enterococci. This enhanced potency extends to the coverage of linezolid-resistant gram-positive microbes, especially multidrug-resistant enterococci and pneumococci. Compounds from this series expand the spectrum compared with linezolid to include fastidious gram-negative organisms like Haemophilus influenzae and Moraxella catarrhalis. Like linezolid, the Rx-01 compounds are bacteriostatic against MRSA and enterococci but are generally bactericidal against S. pneumoniae and H. influenzae. | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18316525 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18316525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18316525 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18316525 | pubmed:month | May | lld:pubmed |
| pubmed-article:18316525 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:18316525 | pubmed:author | pubmed-author:SutcliffeJoyc... | lld:pubmed |
| pubmed-article:18316525 | pubmed:author | pubmed-author:FranceschiFra... | lld:pubmed |
| pubmed-article:18316525 | pubmed:author | pubmed-author:LawrenceLaura... | lld:pubmed |
| pubmed-article:18316525 | pubmed:author | pubmed-author:DanesePaulP | lld:pubmed |
| pubmed-article:18316525 | pubmed:author | pubmed-author:DeVitoJoeJ | lld:pubmed |
| pubmed-article:18316525 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18316525 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:18316525 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18316525 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18316525 | pubmed:pagination | 1653-62 | lld:pubmed |
| pubmed-article:18316525 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:meshHeading | pubmed-meshheading:18316525... | lld:pubmed |
| pubmed-article:18316525 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18316525 | pubmed:articleTitle | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. | lld:pubmed |
| pubmed-article:18316525 | pubmed:affiliation | Rib-X Pharmaceuticals, Inc., 300 George Street, New Haven, Connecticut 06511, USA. | lld:pubmed |
| pubmed-article:18316525 | pubmed:publicationType | Journal Article | lld:pubmed |
