| pubmed-article:18292535 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C0014406 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18292535 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18292535 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18292535 | pubmed:dateCreated | 2008-2-22 | lld:pubmed |
| pubmed-article:18292535 | pubmed:abstractText | CD4+ T cells enhance tumor destruction by CD8+ T cells. One benefit that underlies CD4+ T cell help is enhanced clonal expansion of newly activated CD8+ cells. In addition, tumor-specific CD4+ help is also associated with the accumulation of greater numbers of CD8+ T cells within the tumor. Whether this too is attributable to the effects of help delivered to the CD8+ cells during priming within secondary lymphoid tissues, or alternatively is due to the action of CD4+ cells within the tumor environment has not been examined. In this study, we have evaluated separately the benefits of CD4+ T cell help accrued during priming of tumor-specific CD8+ T cells with a vaccine, as opposed to the benefits delivered by the presence of cognate CD4+ cells within the tumor. The presence of CD4+ T cell help during priming increased clonal expansion of tumor-specific CD8+ T cells in secondary lymphoid tissue; however, CD8+ T cells that have low avidity for tumor Ag were inefficient in tumor invasion. CD4+ T cells that recognized tumor Ag were required to facilitate accumulation of CD8+ T cells within the tumor and enhance tumor lysis during the acute phase of the response. These experiments highlight the ability of tumor-specific CD4+ T cells to render the tumor microenvironment receptive for CD8+ T cell immunotherapy, by facilitating the accumulation of all activated CD8+ T cells, including low-avidity tumor-specific and noncognate cells. | lld:pubmed |
| pubmed-article:18292535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292535 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18292535 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292535 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18292535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292535 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18292535 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18292535 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:18292535 | pubmed:author | pubmed-author:ShermanLinda... | lld:pubmed |
| pubmed-article:18292535 | pubmed:author | pubmed-author:WongS B... | lld:pubmed |
| pubmed-article:18292535 | pubmed:author | pubmed-author:BosRinkeR | lld:pubmed |
| pubmed-article:18292535 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18292535 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18292535 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:18292535 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18292535 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18292535 | pubmed:pagination | 3122-31 | lld:pubmed |
| pubmed-article:18292535 | pubmed:dateRevised | 2011-1-28 | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
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| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:meshHeading | pubmed-meshheading:18292535... | lld:pubmed |
| pubmed-article:18292535 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18292535 | pubmed:articleTitle | Tumor-specific CD4+ T cells render the tumor environment permissive for infiltration by low-avidity CD8+ T cells. | lld:pubmed |
| pubmed-article:18292535 | pubmed:affiliation | Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:18292535 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18292535 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18292535 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18292535 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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