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pubmed-article:18275675pubmed:abstractTextLamivudine (LAM)-resistant hepatitis B virus (HBV) with mutations in the polymerase region frequently appears after long-term use of LAM. Several methods allowing detection of mutant strains (YIDD, YVDD) have been reported, but they have no quantitative characteristics. In this study, we explored a unique approach for quantification of each mutant strain.lld:pubmed
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pubmed-article:18275675pubmed:articleTitleQuantification of lamivudine-resistant hepatitis B virus mutants by type-specific TaqMan minor groove binder probe assay in patients with chronic hepatitis B.lld:pubmed
pubmed-article:18275675pubmed:affiliationDepartment of Health Sciences, Hokkaido University School of Medicine, North-12 West-5, Sapporo, Japan. shiyoshi@med.hokudai.ac.jplld:pubmed
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