Linked Life Data

1827160

Source:http://linkedlifedata.com/resource/pubmed/id/1827160

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pubmed-article:1827160pubmed:abstractTextThe majority of T cells constituting the focal lymphocytic infiltrates in the labial minor salivary glands of patients with Sjögren's syndrome bear the helper phenotype (CD4); activation is expressed by class II (HLA-DR) MHC products. In our immunohistologic study of snap frozen minor salivary gland biopsies from 16 patients with primary Sjögren's syndrome, it was shown that the majority (77%) of the infiltrating T cells exhibit the memory helper/inducer phenotype (UCHL-1) and express LFA-1 molecules. In addition most of the T cells express the alpha beta receptor while only 2.8% express the gamma delta receptor. Our findings suggest that these T cell infiltrates in patients with primary Sjögren's syndrome may explain the intense B lymphocyte hyperreactivity observed in the exocrine glands of patients with Sjögren's syndrome.lld:pubmed
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pubmed-article:1827160pubmed:articleTitleT cell subpopulations in the labial minor salivary gland histopathologic lesion of Sjögren's syndrome.lld:pubmed
pubmed-article:1827160pubmed:affiliationDepartment of Internal Medicine, Medical School, University of Ioannina, Greece.lld:pubmed
pubmed-article:1827160pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1827160pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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