| pubmed-article:18268325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18268325 | lifeskim:mentions | umls-concept:C1159909 | lld:lifeskim |
| pubmed-article:18268325 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:18268325 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18268325 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:18268325 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18268325 | pubmed:dateCreated | 2008-2-21 | lld:pubmed |
| pubmed-article:18268325 | pubmed:abstractText | Cell-cycle exit and differentiation of suprabasal epidermal keratinocytes require nuclear IkappaB kinase alpha (IKKalpha), but not its protein kinase activity. IKKalpha also is a suppressor of squamous cell carcinoma (SCC), but its mode of action remains elusive. Postulating that IKKalpha may serve as a transcriptional regulator in keratinocytes, we searched for cell-cycle-related genes that could illuminate this function. IKKalpha was found to control several Myc antagonists, including Mad1, Mad2, and Ovol1, through the association with TGFbeta-regulated Smad2/3 transcription factors and is required for Smad3 recruitment to at least one of these targets. Surprisingly, Smad2/3-dependent Mad1 induction and keratinocyte differentiation are independent of Smad4, the almost universal coregulator of canonical TGFbeta signaling. IKKalpha also is needed for nuclear accumulation of activated Smad2/3 in the epidermis, and Smad2/3 are required for epidermal differentiation. We suggest that a TGFbeta-Smad2/3-IKKalpha axis is a critical Smad4-independent regulator of keratinocyte proliferation and differentiation. | lld:pubmed |
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| pubmed-article:18268325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18268325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18268325 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18268325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18268325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18268325 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18268325 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:KarinMichaelM | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:WangXiao-Jing... | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:SilAlok KAK | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:SanoYujiY | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:HanGangwenG | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:DescarguesPas... | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:OwensPhilipP | lld:pubmed |
| pubmed-article:18268325 | pubmed:author | pubmed-author:KorchynskyiOl... | lld:pubmed |
| pubmed-article:18268325 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18268325 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:18268325 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:18268325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18268325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18268325 | pubmed:pagination | 2487-92 | lld:pubmed |
| pubmed-article:18268325 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18268325 | pubmed:meshHeading | pubmed-meshheading:18268325... | lld:pubmed |
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| pubmed-article:18268325 | pubmed:meshHeading | pubmed-meshheading:18268325... | lld:pubmed |
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| pubmed-article:18268325 | pubmed:meshHeading | pubmed-meshheading:18268325... | lld:pubmed |
| pubmed-article:18268325 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18268325 | pubmed:articleTitle | IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. | lld:pubmed |
| pubmed-article:18268325 | pubmed:affiliation | Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA. | lld:pubmed |
| pubmed-article:18268325 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18268325 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18268325 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
